Stress-induced plasticity of dynamic collagen networks

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dc.citation.articleNumber842
dc.citation.journalTitleNature Communications
dc.citation.volumeNumber8
dc.contributor.authorKim, Jihan
dc.contributor.authorFeng, Jingchen
dc.contributor.authorJones, Christopher A.R.
dc.contributor.authorMao, Xiaoming
dc.contributor.authorSander, Leonard M.
dc.contributor.authorLevine, Herbert
dc.contributor.authorSun, Bo
dc.date.accessioned2017-11-06T21:15:05Z
dc.date.available2017-11-06T21:15:05Z
dc.date.issued2017
dc.description.abstractThe structure and mechanics of tissues is constantly perturbed by endogenous forces originated from cells, and at the same time regulate many important cellular functions such as migration, differentiation, and growth. Here we show that 3D collagen gels, major components of connective tissues and extracellular matrix (ECM), are significantly and irreversibly remodeled by cellular traction forces, as well as by macroscopic strains. To understand this ECM plasticity, we develop a computational model that takes into account the sliding and merging of ECM fibers. We have confirmed the model predictions with experiment. Our results suggest the profound impacts of cellular traction forces on their host ECM during development and cancer progression, and suggest indirect mechanical channels of cell-cell communications in 3D fibrous matrices.
dc.identifier.citationKim, Jihan, Feng, Jingchen, Jones, Christopher A.R., et al.. "Stress-induced plasticity of dynamic collagen networks." <i>Nature Communications,</i> 8, (2017) Springer Nature: https://doi.org/10.1038/s41467-017-01011-7.
dc.identifier.digitalStress-induced_plasticity
dc.identifier.doihttps://doi.org/10.1038/s41467-017-01011-7
dc.identifier.urihttps://hdl.handle.net/1911/97834
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleStress-induced plasticity of dynamic collagen networks
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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