Stress-induced plasticity of dynamic collagen networks

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dc.citation.articleNumber842en_US
dc.citation.journalTitleNature Communicationsen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorKim, Jihanen_US
dc.contributor.authorFeng, Jingchenen_US
dc.contributor.authorJones, Christopher A.R.en_US
dc.contributor.authorMao, Xiaomingen_US
dc.contributor.authorSander, Leonard M.en_US
dc.contributor.authorLevine, Herberten_US
dc.contributor.authorSun, Boen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2017-11-06T21:15:05Zen_US
dc.date.available2017-11-06T21:15:05Zen_US
dc.date.issued2017en_US
dc.description.abstractThe structure and mechanics of tissues is constantly perturbed by endogenous forces originated from cells, and at the same time regulate many important cellular functions such as migration, differentiation, and growth. Here we show that 3D collagen gels, major components of connective tissues and extracellular matrix (ECM), are significantly and irreversibly remodeled by cellular traction forces, as well as by macroscopic strains. To understand this ECM plasticity, we develop a computational model that takes into account the sliding and merging of ECM fibers. We have confirmed the model predictions with experiment. Our results suggest the profound impacts of cellular traction forces on their host ECM during development and cancer progression, and suggest indirect mechanical channels of cell-cell communications in 3D fibrous matrices.en_US
dc.identifier.citationKim, Jihan, Feng, Jingchen, Jones, Christopher A.R., et al.. "Stress-induced plasticity of dynamic collagen networks." <i>Nature Communications,</i> 8, (2017) Springer Nature: https://doi.org/10.1038/s41467-017-01011-7.en_US
dc.identifier.digitalStress-induced_plasticityen_US
dc.identifier.doihttps://doi.org/10.1038/s41467-017-01011-7en_US
dc.identifier.urihttps://hdl.handle.net/1911/97834en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleStress-induced plasticity of dynamic collagen networksen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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