Development of Functionalized Carbon Nano-Onions Reinforced Zein Protein Hydrogel Interfaces for Controlled Drug Release

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dc.citation.articleNumber621en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitlePharmaceuticsen_US
dc.citation.volumeNumber11en_US
dc.contributor.authorMamidi, Narsimhaen_US
dc.contributor.authorGonzález-Ortiz, Aldoen_US
dc.contributor.authorLopez Romo, Irasemaen_US
dc.contributor.authorBarrera, Enrique V.en_US
dc.date.accessioned2020-02-14T16:39:49Zen_US
dc.date.available2020-02-14T16:39:49Zen_US
dc.date.issued2019en_US
dc.description.abstractIn the current study, poly 4-mercaptophenyl methacrylate-carbon nano-onions (PMPMA-CNOs = f-CNOs) reinforced natural protein (zein) composites (zein/f-CNOs) are fabricated using the acoustic cavitation technique. The influence of f-CNOs inclusion on the microstructural properties, morphology, mechanical, cytocompatibility, in-vitro degradation, and swelling behavior of the hydrogels are studied. The tensile results showed that zein/f-CNOs hydrogels fabricated by the acoustic cavitation system exhibited good tensile strength (90.18 MPa), compared with the hydrogels fabricated by the traditional method and only microwave radiation method. It reveals the magnitude of physisorption and degree of colloidal stability of f-CNOs within the zein matrix under acoustic cavitation conditions. The swelling behaviors of hydrogels were also tested and improved results were noticed. The cytotoxicity of hydrogels was tested with osteoblast cells. The results showed good cell viability and cell growth. To explore the efficacy of hydrogels as drug transporters, 5-fluorouracil (5-FU) release was measured under gastric and intestinal pH environment. The results showed pH-responsive sustained drug release over 15 days of study, and pH 7.4 showed a more rapid drug release than pH 2.0 and 4.5. Nonetheless, all the results suggest that zein/f-CNOs hydrogel could be a potential pH-responsive drug transporter for a colon-selective delivery system.en_US
dc.identifier.citationMamidi, Narsimha, González-Ortiz, Aldo, Lopez Romo, Irasema, et al.. "Development of Functionalized Carbon Nano-Onions Reinforced Zein Protein Hydrogel Interfaces for Controlled Drug Release." <i>Pharmaceutics,</i> 11, no. 12 (2019) MDPI: https://doi.org/10.3390/pharmaceutics11120621.en_US
dc.identifier.digitalpharmaceutics-11-00621-v2en_US
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics11120621en_US
dc.identifier.urihttps://hdl.handle.net/1911/108047en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordzein/poly 4-mercaptophenyl methacrylate-carbon nano-onions hydrogelsen_US
dc.subject.keywordacoustic cavitation methoden_US
dc.subject.keywordpH-responsive drug releaseen_US
dc.subject.keywordcytocompatibilityen_US
dc.titleDevelopment of Functionalized Carbon Nano-Onions Reinforced Zein Protein Hydrogel Interfaces for Controlled Drug Releaseen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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