Point-of-Care Imaging and Lateral Flow Diagnostics for Improving Medical Care in Low-Resource Settings

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dc.contributor.advisorRichards-Kortum, Rebecca
dc.creatorKeahey, Pelham Anderson
dc.date.accessioned2019-05-17T13:35:37Z
dc.date.available2019-05-17T13:35:37Z
dc.date.created2018-05
dc.date.issued2018-01-11
dc.date.submittedMay 2018
dc.date.updated2019-05-17T13:35:37Z
dc.description.abstractMedical advances often ineffectively translate to low-resource settings which can hamper improvements for patients in low and middle income countries (LMICs). The objective of this work was to develop diagnostics to improve patient care in low-resource settings in two areas: (1) cervical cancer diagnosis using high resolution microendoscopy and (2) neonatal jaundice diagnosis using a lateral flow test. (1) Over 260,000 women each year die from cervical cancer, with over 80% of these deaths occurring in low and middle-income countries (LMICs). To reduce mortality in low-income areas from cervical cancer, early screening and diagnosis needs to be improved. To address this, this work details the development of differential structured illumination microendoscopy (DSIMe) for obtaining histological information in highly scattering tissue in vivo to improve the early detection of cervical cancer. (2) Neonatal jaundice, a condition caused by the accumulation of bilirubin in the blood stream, affects approximately half of all newborns and causes permanent neurological damage and mortality if untreated. Jaundice regularly goes undetected in low-resource settings due to a lack of diagnostic tools to measure bilirubin levels. This work details the development of BiliSpec, a novel low-cost method to measure total bilirubin at the point-of-care in low-resource settings to improve care for neonates suffering from jaundice.
dc.format.mimetypeapplication/pdf
dc.identifier.citationKeahey, Pelham Anderson. "Point-of-Care Imaging and Lateral Flow Diagnostics for Improving Medical Care in Low-Resource Settings." (2018) Diss., Rice University. <a href="https://hdl.handle.net/1911/105614">https://hdl.handle.net/1911/105614</a>.
dc.identifier.urihttps://hdl.handle.net/1911/105614
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectmicroendoscopy
dc.subjectcervical cancer
dc.subjectstructured illumination
dc.subjectlateral flow
dc.subjectjaundice
dc.subjectlow-resource setting
dc.titlePoint-of-Care Imaging and Lateral Flow Diagnostics for Improving Medical Care in Low-Resource Settings
dc.typeThesis
dc.type.materialText
thesis.degree.departmentApplied Physics
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.majorApplied Physics/Bioengineering
thesis.degree.nameDoctor of Philosophy
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