Intracellular microRNA quantification in intact cells: a novel strategy based on reduced graphene oxide-based fluorescence quenching

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dc.citation.firstpage642
dc.citation.issueNumber3
dc.citation.journalTitleMRS Communications
dc.citation.lastpage651
dc.citation.volumeNumber8
dc.contributor.authorPaulmurugan, Ramasamy
dc.contributor.authorAjayan, Pulickel M.
dc.contributor.authorLiepmann, Dorian
dc.contributor.authorRenugopalakrishnan, V.
dc.date.accessioned2019-11-22T16:19:59Z
dc.date.available2019-11-22T16:19:59Z
dc.date.issued2018
dc.description.abstractNanomaterials have been proposed as key components in biosensing, imaging, and drug delivery since they offer distinctive advantages over conventional approaches. The unique chemical and physical properties of graphene make it possible to functionalize and develop protein transducers, therapeutic delivery vehicles, and microbial diagnostics. In this study, we evaluate reduced graphene oxide as a potential nanomaterial for quantification of microRNAs including their structural differentiation in vitro in solution and inside intact cells. Our results provide evidence for the potential use of graphene nanomaterials as a platform for developing devices that can be used for microRNA quantitation as biomarkers for clinical applications.
dc.identifier.citationPaulmurugan, Ramasamy, Ajayan, Pulickel M., Liepmann, Dorian, et al.. "Intracellular microRNA quantification in intact cells: a novel strategy based on reduced graphene oxide-based fluorescence quenching." <i>MRS Communications,</i> 8, no. 3 (2018) Cambridge University Press: 642-651. https://doi.org/10.1557/mrc.2018.120.
dc.identifier.digitalnihms978089
dc.identifier.doihttps://doi.org/10.1557/mrc.2018.120
dc.identifier.urihttps://hdl.handle.net/1911/107726
dc.language.isoeng
dc.publisherCambridge University Press
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Materials Research Society
dc.titleIntracellular microRNA quantification in intact cells: a novel strategy based on reduced graphene oxide-based fluorescence quenching
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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