Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane

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dc.citation.articleNumbereabm2055en_US
dc.citation.issueNumber22en_US
dc.citation.journalTitleScience Advancesen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorSantos, Ana L.en_US
dc.contributor.authorLiu, Dongdongen_US
dc.contributor.authorReed, Anna K.en_US
dc.contributor.authorWyderka, Aaron M.en_US
dc.contributor.authorvan Venrooy, Alexisen_US
dc.contributor.authorLi, John T.en_US
dc.contributor.authorLi, Victor D.en_US
dc.contributor.authorMisiura, Mikitaen_US
dc.contributor.authorSamoylova, Olgaen_US
dc.contributor.authorBeckham, Jacob L.en_US
dc.contributor.authorAyala-Orozco, Ciceronen_US
dc.contributor.authorKolomeisky, Anatoly B.en_US
dc.contributor.authorAlemany, Lawrence B.en_US
dc.contributor.authorOliver, Antonioen_US
dc.contributor.authorTegos, George P.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.orgSmalley-Curl Instituteen_US
dc.contributor.orgNanoCarbon Centeren_US
dc.contributor.orgWelch Institute for Advanced Materialsen_US
dc.date.accessioned2022-07-06T18:09:18Zen_US
dc.date.available2022-07-06T18:09:18Zen_US
dc.date.issued2022en_US
dc.description.abstractThe increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible (405 nanometers) light-activated synthetic molecular machines (MMs) to kill Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, in minutes, vastly outpacing conventional antibiotics. MMs also rapidly eliminate persister cells and established bacterial biofilms. The antibacterial mode of action of MMs involves physical disruption of the membrane. In addition, by permeabilizing the membrane, MMs at sublethal doses potentiate the action of conventional antibiotics. Repeated exposure to antibacterial MMs is not accompanied by resistance development. Finally, therapeutic doses of MMs mitigate mortality associated with bacterial infection in an in vivo model of burn wound infection. Visible light–activated MMs represent an unconventional antibacterial mode of action by mechanical disruption at the molecular scale, not existent in nature and to which resistance development is unlikely.en_US
dc.identifier.citationSantos, Ana L., Liu, Dongdong, Reed, Anna K., et al.. "Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane." <i>Science Advances,</i> 8, no. 22 (2022) AAAS: https://doi.org/10.1126/sciadv.abm2055.en_US
dc.identifier.digitalsciadv-abm2055en_US
dc.identifier.doihttps://doi.org/10.1126/sciadv.abm2055en_US
dc.identifier.urihttps://hdl.handle.net/1911/112682en_US
dc.language.isoengen_US
dc.publisherAAASen_US
dc.rightsDistributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.titleLight-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membraneen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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