Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane

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dc.citation.articleNumbereabm2055
dc.citation.issueNumber22
dc.citation.journalTitleScience Advances
dc.citation.volumeNumber8
dc.contributor.authorSantos, Ana L.
dc.contributor.authorLiu, Dongdong
dc.contributor.authorReed, Anna K.
dc.contributor.authorWyderka, Aaron M.
dc.contributor.authorvan Venrooy, Alexis
dc.contributor.authorLi, John T.
dc.contributor.authorLi, Victor D.
dc.contributor.authorMisiura, Mikita
dc.contributor.authorSamoylova, Olga
dc.contributor.authorBeckham, Jacob L.
dc.contributor.authorAyala-Orozco, Ciceron
dc.contributor.authorKolomeisky, Anatoly B.
dc.contributor.authorAlemany, Lawrence B.
dc.contributor.authorOliver, Antonio
dc.contributor.authorTegos, George P.
dc.contributor.authorTour, James M.
dc.contributor.orgSmalley-Curl Institute
dc.contributor.orgNanoCarbon Center
dc.contributor.orgWelch Institute for Advanced Materials
dc.date.accessioned2022-07-06T18:09:18Z
dc.date.available2022-07-06T18:09:18Z
dc.date.issued2022
dc.description.abstractThe increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible (405 nanometers) light-activated synthetic molecular machines (MMs) to kill Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, in minutes, vastly outpacing conventional antibiotics. MMs also rapidly eliminate persister cells and established bacterial biofilms. The antibacterial mode of action of MMs involves physical disruption of the membrane. In addition, by permeabilizing the membrane, MMs at sublethal doses potentiate the action of conventional antibiotics. Repeated exposure to antibacterial MMs is not accompanied by resistance development. Finally, therapeutic doses of MMs mitigate mortality associated with bacterial infection in an in vivo model of burn wound infection. Visible light–activated MMs represent an unconventional antibacterial mode of action by mechanical disruption at the molecular scale, not existent in nature and to which resistance development is unlikely.
dc.identifier.citationSantos, Ana L., Liu, Dongdong, Reed, Anna K., et al.. "Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane." <i>Science Advances,</i> 8, no. 22 (2022) AAAS: https://doi.org/10.1126/sciadv.abm2055.
dc.identifier.digitalsciadv-abm2055
dc.identifier.doihttps://doi.org/10.1126/sciadv.abm2055
dc.identifier.urihttps://hdl.handle.net/1911/112682
dc.language.isoeng
dc.publisherAAAS
dc.rightsDistributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleLight-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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