Improved Analysis for Determining Diffusion Coefficients from Short, Single-Molecule Trajectories with Photoblinking

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dc.citation.firstpage228
dc.citation.issueNumber1
dc.citation.journalTitleLangmuir
dc.citation.lastpage234
dc.citation.volumeNumber29
dc.contributor.authorShuang, Bo
dc.contributor.authorByers, Chad P.
dc.contributor.authorKisley, Lydia
dc.contributor.authorWang, Lin-Yung
dc.contributor.authorZhao, Julia
dc.contributor.authorMorimura, Hiroyuki
dc.contributor.authorLink, Stephan
dc.contributor.authorLandes, Christy F.
dc.contributor.orgRice Quantum Institute
dc.date.accessioned2014-12-15T20:35:10Z
dc.date.available2014-12-15T20:35:10Z
dc.date.issued2013
dc.description.abstractTwo Maximum Likelihood Estimation (MLE) methods were developed for optimizing the analysis of single-molecule trajectories that include phenomena such as experimental noise, photoblinking, photobleaching, and translation or rotation out of the collection plane. In particular,short, single-molecule trajectories with photoblinking were studied, and our method was compared with existing analytical techniques applied to simulated data. The optimal method for various experimental cases was established, and the optimized MLE method was applied to a real experimental system: single-molecule diffusion of fluorescent molecular machines known as nanocars.
dc.identifier.citationShuang, Bo, Byers, Chad P., Kisley, Lydia, et al.. "Improved Analysis for Determining Diffusion Coefficients from Short, Single-Molecule Trajectories with Photoblinking." <i>Langmuir,</i> 29, no. 1 (2013) American Chemical Society: 228-234. http://dx.doi.org/10.1021/la304063j.
dc.identifier.doihttp://dx.doi.org/10.1021/la304063j
dc.identifier.urihttps://hdl.handle.net/1911/78758
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.titleImproved Analysis for Determining Diffusion Coefficients from Short, Single-Molecule Trajectories with Photoblinking
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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