Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements

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dc.citation.journalTitleLab on a Chipen_US
dc.contributor.authorMcRae, Michael P.en_US
dc.contributor.authorSimmons, Glennon W.en_US
dc.contributor.authorWong, Jorgeen_US
dc.contributor.authorShadfan, Basilen_US
dc.contributor.authorGopalkrishnan, Sanjiven_US
dc.contributor.authorChristodoulides, Nicolaosen_US
dc.contributor.authorMcDevitt, John T.en_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgChemistryen_US
dc.contributor.orgMechanical Engineeringen_US
dc.date.accessioned2015-09-24T18:13:01Zen_US
dc.date.available2015-09-24T18:13:01Zen_US
dc.date.issued2015en_US
dc.description.abstractThe development of integrated instrumentation for universal bioassay systems serves as a key goal for the lab-on-a-chip community. The programmable bio-nano-chip (p-BNC) system is a versatile multiplexed and multiclass chemical- and bio-sensing system for bioscience and clinical measurements. The system is comprised of two main components, a disposable cartridge and a portable analyzer. The customizable single-use plastic cartridges, which now can be manufactured in high volumes using injection molding, are designed for analytical performance, ease of use, reproducibility, and low cost. These labcard devices implement high surface area nano-structured biomarker capture elements that enable high performance signaling and are index-matched to real-world biological specimens. This detection modality, along with the convenience of on-chip fluid storage in blisters and self-contained waste, represents a standard process to digitize biological signatures at the point-of-care. A companion portable analyzer prototype has been developed to integrate fluid motivation, optical detection, and automated data analysis, and it serves as the human interface for complete assay automation. In this report, we provide a systems-level perspective of the p-BNC universal biosensing platform with an emphasis on flow control, device integration, and automation. To demonstrate the flexibility of the p-BNC, we distinguish diseased and non-case patients across three significant disease applications: prostate cancer, ovarian cancer, and acute myocardial infarction. Progress towards developing a rapid 7 minute myoglobin assay is presented using the fully automated p-BNC system.en_US
dc.identifier.citationMcRae, Michael P., Simmons, Glennon W., Wong, Jorge, et al.. "Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements." <i>Lab on a Chip,</i> (2015) Royal Society of Chemistry: http://dx.doi.org/10.1039/C5LC00636H.en_US
dc.identifier.doihttp://dx.doi.org/10.1039/C5LC00636Hen_US
dc.identifier.urihttps://hdl.handle.net/1911/81712en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.en_US
dc.titleProgrammable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurementsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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