Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells

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dc.citation.firstpage154
dc.citation.journalTitleBiomaterials
dc.citation.lastpage163
dc.citation.volumeNumber161
dc.contributor.authorMoore, Amanda N.
dc.contributor.authorLopez Silva, Tania L.
dc.contributor.authorCarrejo, Nicole C.
dc.contributor.authorOrigel Marmolejo, Carlos A.
dc.contributor.authorLi, I-Che
dc.contributor.authorHartgerink, Jeffrey D.
dc.date.accessioned2019-12-11T15:44:27Z
dc.date.available2019-12-11T15:44:27Z
dc.date.issued2018
dc.description.abstractThe design of materials for regenerative medicine has focused on delivery of small molecule drugs, proteins, and cells to help accelerate healing. Additionally, biomaterials have been designed with covalently attached mimics of growth factors, cytokines, or key extracellular matrix components allowing the biomaterial itself to drive biological response. While the approach may vary, the goal of biomaterial design has often centered on promoting either cellular infiltration, degradation, vascularization, or innervation of the scaffold. Numerous successful studies have utilized this complex, multicomponent approach; however, we demonstrate here that a simple nanofibrous peptide hydrogel unexpectedly and innately promotes all of these regenerative responses when subcutaneously implanted into the dorsal tissue of healthy rats. Despite containing no small molecule drugs, cells, proteins or protein mimics, the innate response to this material results in rapid cellular infiltration, production of a wide range of cytokines and growth factors by the infiltrating cells, and remodeling of the synthetic material to a natural collagen-containing ECM. During the remodeling process, a strong angiogenic response and an unprecedented degree of innervation is observed. Collectively, this simple peptide-based material provides an ideal foundational system for a variety of bioregenerative approaches.
dc.identifier.citationMoore, Amanda N., Lopez Silva, Tania L., Carrejo, Nicole C., et al.. "Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells." <i>Biomaterials,</i> 161, (2018) Elsevier: 154-163. https://doi.org/10.1016/j.biomaterials.2018.01.033.
dc.identifier.digitalnihms939832
dc.identifier.doihttps://doi.org/10.1016/j.biomaterials.2018.01.033
dc.identifier.urihttps://hdl.handle.net/1911/107860
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.subject.keywordBiomaterials
dc.subject.keywordSelf-assembly
dc.subject.keywordPeptide
dc.subject.keywordHydrogel
dc.subject.keywordInnervation
dc.subject.keywordVascularization
dc.titleNanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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