Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells

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dc.citation.firstpage154en_US
dc.citation.journalTitleBiomaterialsen_US
dc.citation.lastpage163en_US
dc.citation.volumeNumber161en_US
dc.contributor.authorMoore, Amanda N.en_US
dc.contributor.authorLopez Silva, Tania L.en_US
dc.contributor.authorCarrejo, Nicole C.en_US
dc.contributor.authorOrigel Marmolejo, Carlos A.en_US
dc.contributor.authorLi, I-Cheen_US
dc.contributor.authorHartgerink, Jeffrey D.en_US
dc.date.accessioned2019-12-11T15:44:27Zen_US
dc.date.available2019-12-11T15:44:27Zen_US
dc.date.issued2018en_US
dc.description.abstractThe design of materials for regenerative medicine has focused on delivery of small molecule drugs, proteins, and cells to help accelerate healing. Additionally, biomaterials have been designed with covalently attached mimics of growth factors, cytokines, or key extracellular matrix components allowing the biomaterial itself to drive biological response. While the approach may vary, the goal of biomaterial design has often centered on promoting either cellular infiltration, degradation, vascularization, or innervation of the scaffold. Numerous successful studies have utilized this complex, multicomponent approach; however, we demonstrate here that a simple nanofibrous peptide hydrogel unexpectedly and innately promotes all of these regenerative responses when subcutaneously implanted into the dorsal tissue of healthy rats. Despite containing no small molecule drugs, cells, proteins or protein mimics, the innate response to this material results in rapid cellular infiltration, production of a wide range of cytokines and growth factors by the infiltrating cells, and remodeling of the synthetic material to a natural collagen-containing ECM. During the remodeling process, a strong angiogenic response and an unprecedented degree of innervation is observed. Collectively, this simple peptide-based material provides an ideal foundational system for a variety of bioregenerative approaches.en_US
dc.identifier.citationMoore, Amanda N., Lopez Silva, Tania L., Carrejo, Nicole C., et al.. "Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells." <i>Biomaterials,</i> 161, (2018) Elsevier: 154-163. https://doi.org/10.1016/j.biomaterials.2018.01.033.en_US
dc.identifier.digitalnihms939832en_US
dc.identifier.doihttps://doi.org/10.1016/j.biomaterials.2018.01.033en_US
dc.identifier.urihttps://hdl.handle.net/1911/107860en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordBiomaterialsen_US
dc.subject.keywordSelf-assemblyen_US
dc.subject.keywordPeptideen_US
dc.subject.keywordHydrogelen_US
dc.subject.keywordInnervationen_US
dc.subject.keywordVascularizationen_US
dc.titleNanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cellsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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