From START to FINISH: The Influence of Osmotic Stress on the Cell Cycle

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dc.citation.firstpagee68067en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitlePLoS ONEen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorRadmaneshfar, Elaheen_US
dc.contributor.authorKaloriti, Despoinaen_US
dc.contributor.authorGustin, Michael C.en_US
dc.contributor.authorGow, Neil A.R.en_US
dc.contributor.authorBrown, Alistair J.P.en_US
dc.contributor.authorGrebogi, Celsoen_US
dc.contributor.authorRomano, M.Carmenen_US
dc.contributor.authorThiel, Marcoen_US
dc.date.accessioned2016-01-29T22:36:34Zen_US
dc.date.available2016-01-29T22:36:34Zen_US
dc.date.issued2013en_US
dc.description.abstractThe cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of different conditions. Environmental changes are transmitted by molecular signalling networks, which coordinate their action with the cell cycle. The cell cycle process and its responses to environmental stresses arise from intertwined nonlinear interactions among large numbers of simpler components. Yet, understanding of how these pieces fit together into a coherent whole requires a systems biology approach. Here, we present a novel mathematical model that describes the influence of osmotic stress on the entire cell cycle ofﾠS. cerevisiaefor the first time. Our model incorporates all recently known and several proposed interactions between the osmotic stress response pathway and the cell cycle. This model unveils the mechanisms that emerge as a consequence of the interaction between the cell cycle and stress response networks. Furthermore, it characterises the role of individual components. Moreover, it predicts different phenotypical responses for cells depending on the phase of cells at the onset of the stress. The key predictions of the model are: (i) exposure of cells to osmotic stress during the late S and the early G2/M phase can induce DNA re-replication before cell division occurs, (ii) cells stressed at the late G2/M phase display accelerated exit from mitosis and arrest in the next cell cycle, (iii) osmotic stress delays the G1-to-S and G2-to-M transitions in a dose dependent manner, whereas it accelerates the M-to-G1 transition independently of the stress dose and (iv) the Hog MAPK network compensates the role of the MEN network during cell division of MEN mutant cells. These model predictions are supported by independent experiments inﾠS. cerevisiaeﾠand, moreover, have recently been observed in other eukaryotes.en_US
dc.identifier.citationRadmaneshfar, Elahe, Kaloriti, Despoina, Gustin, Michael C., et al.. "From START to FINISH: The Influence of Osmotic Stress on the Cell Cycle." <i>PLoS ONE,</i> 8, no. 7 (2013) Public Library of Science: e68067. http://dx.doi.org/10.1371/journal.pone.0068067.en_US
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0068067en_US
dc.identifier.urihttps://hdl.handle.net/1911/88290en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/en_US
dc.titleFrom START to FINISH: The Influence of Osmotic Stress on the Cell Cycleen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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