Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma

Simple item page
dc.citation.firstpage1121
dc.citation.issueNumber6
dc.citation.journalTitleNanomedicine: Nanotechnology, Biology and Medicine
dc.citation.lastpage1130
dc.citation.volumeNumber10
dc.contributor.authorRaoof, Mustafa
dc.contributor.authorCorr, Stuart J.
dc.contributor.authorZhu, Cihui
dc.contributor.authorCisneros, Brandon T.
dc.contributor.authorKaluarachchi, Warna D.
dc.contributor.authorPhounsavath, Sophia
dc.contributor.authorWilson, Lon J.
dc.contributor.authorCurley, Steven A.
dc.contributor.orgRichard E. Smalley Institute for Nanoscale Science & Technology
dc.date.accessioned2017-06-15T15:30:09Z
dc.date.available2017-06-15T15:30:09Z
dc.date.issued2014
dc.description.abstractHepatocellular carcinoma (HCC) is one of the most lethal and chemo-refractory cancers, clearly, alternative treatment strategies are needed. We utilized 10 nm gold nanoparticles as a scaffold to synthesize nanoconjugates bearing a targeting antibody (cetuximab, C225) and gemcitabine. Loading efficiency of gemcitabine on the gold nanoconjugates was 30%. Targeted gold nanoconjugates in combination with RF were selectively cytotoxic to EGFR expressing Hep3B and SNU449 cells when compared to isotype particles with/without RF (P < 0.05). In animal experiments, targeted gold nanoconjugates halted the growth of subcutaneous Hep3B xenografts in combination with RF exposure (P < 0.05). These xenografts also demonstrated increased apoptosis, necrosis and decreased proliferation compared to controls. Normal tissues were unharmed. We have demonstrated that non-invasive RF-induced hyperthermia when combined with targeted delivery of gemcitabine is more effective and safe at dosages ~ 275-fold lower than the current clinically-delivered systemic dose of gemcitabine.
dc.identifier.citationRaoof, Mustafa, Corr, Stuart J., Zhu, Cihui, et al.. "Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma." <i>Nanomedicine: Nanotechnology, Biology and Medicine,</i> 10, no. 6 (2014) Elsevier: 1121-1130. https://doi.org/10.1016/j.nano.2014.03.004.
dc.identifier.doihttps://doi.org/10.1016/j.nano.2014.03.004
dc.identifier.urihttps://hdl.handle.net/1911/94861
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.subject.keywordGemcitabine
dc.subject.keywordHepatocellular
dc.subject.keywordHyperthermia
dc.subject.keywordNanoparticle
dc.subject.keywordRadiofrequency
dc.titleGold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Radiofrequency.pdf
Size:
2.61 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Chemistry Publications