Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma
dc.citation.firstpage | 1121 | en_US |
dc.citation.issueNumber | 6 | en_US |
dc.citation.journalTitle | Nanomedicine: Nanotechnology, Biology and Medicine | en_US |
dc.citation.lastpage | 1130 | en_US |
dc.citation.volumeNumber | 10 | en_US |
dc.contributor.author | Raoof, Mustafa | en_US |
dc.contributor.author | Corr, Stuart J. | en_US |
dc.contributor.author | Zhu, Cihui | en_US |
dc.contributor.author | Cisneros, Brandon T. | en_US |
dc.contributor.author | Kaluarachchi, Warna D. | en_US |
dc.contributor.author | Phounsavath, Sophia | en_US |
dc.contributor.author | Wilson, Lon J. | en_US |
dc.contributor.author | Curley, Steven A. | en_US |
dc.contributor.org | Richard E. Smalley Institute for Nanoscale Science & Technology | en_US |
dc.date.accessioned | 2017-06-15T15:30:09Z | en_US |
dc.date.available | 2017-06-15T15:30:09Z | en_US |
dc.date.issued | 2014 | en_US |
dc.description.abstract | Hepatocellular carcinoma (HCC) is one of the most lethal and chemo-refractory cancers, clearly, alternative treatment strategies are needed. We utilized 10 nm gold nanoparticles as a scaffold to synthesize nanoconjugates bearing a targeting antibody (cetuximab, C225) and gemcitabine. Loading efficiency of gemcitabine on the gold nanoconjugates was 30%. Targeted gold nanoconjugates in combination with RF were selectively cytotoxic to EGFR expressing Hep3B and SNU449 cells when compared to isotype particles with/without RF (P < 0.05). In animal experiments, targeted gold nanoconjugates halted the growth of subcutaneous Hep3B xenografts in combination with RF exposure (P < 0.05). These xenografts also demonstrated increased apoptosis, necrosis and decreased proliferation compared to controls. Normal tissues were unharmed. We have demonstrated that non-invasive RF-induced hyperthermia when combined with targeted delivery of gemcitabine is more effective and safe at dosages ~ 275-fold lower than the current clinically-delivered systemic dose of gemcitabine. | en_US |
dc.identifier.citation | Raoof, Mustafa, Corr, Stuart J., Zhu, Cihui, et al.. "Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma." <i>Nanomedicine: Nanotechnology, Biology and Medicine,</i> 10, no. 6 (2014) Elsevier: 1121-1130. https://doi.org/10.1016/j.nano.2014.03.004. | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.nano.2014.03.004 | en_US |
dc.identifier.uri | https://hdl.handle.net/1911/94861 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier. | en_US |
dc.subject.keyword | Gemcitabine | en_US |
dc.subject.keyword | Hepatocellular | en_US |
dc.subject.keyword | Hyperthermia | en_US |
dc.subject.keyword | Nanoparticle | en_US |
dc.subject.keyword | Radiofrequency | en_US |
dc.title | Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma | en_US |
dc.type | Journal article | en_US |
dc.type.dcmi | Text | en_US |
dc.type.publication | post-print | en_US |
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