Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma

dc.citation.firstpage1121en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleNanomedicine: Nanotechnology, Biology and Medicineen_US
dc.citation.lastpage1130en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorRaoof, Mustafaen_US
dc.contributor.authorCorr, Stuart J.en_US
dc.contributor.authorZhu, Cihuien_US
dc.contributor.authorCisneros, Brandon T.en_US
dc.contributor.authorKaluarachchi, Warna D.en_US
dc.contributor.authorPhounsavath, Sophiaen_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.authorCurley, Steven A.en_US
dc.contributor.orgRichard E. Smalley Institute for Nanoscale Science & Technologyen_US
dc.date.accessioned2017-06-15T15:30:09Zen_US
dc.date.available2017-06-15T15:30:09Zen_US
dc.date.issued2014en_US
dc.description.abstractHepatocellular carcinoma (HCC) is one of the most lethal and chemo-refractory cancers, clearly, alternative treatment strategies are needed. We utilized 10 nm gold nanoparticles as a scaffold to synthesize nanoconjugates bearing a targeting antibody (cetuximab, C225) and gemcitabine. Loading efficiency of gemcitabine on the gold nanoconjugates was 30%. Targeted gold nanoconjugates in combination with RF were selectively cytotoxic to EGFR expressing Hep3B and SNU449 cells when compared to isotype particles with/without RF (P < 0.05). In animal experiments, targeted gold nanoconjugates halted the growth of subcutaneous Hep3B xenografts in combination with RF exposure (P < 0.05). These xenografts also demonstrated increased apoptosis, necrosis and decreased proliferation compared to controls. Normal tissues were unharmed. We have demonstrated that non-invasive RF-induced hyperthermia when combined with targeted delivery of gemcitabine is more effective and safe at dosages ~ 275-fold lower than the current clinically-delivered systemic dose of gemcitabine.en_US
dc.identifier.citationRaoof, Mustafa, Corr, Stuart J., Zhu, Cihui, et al.. "Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma." <i>Nanomedicine: Nanotechnology, Biology and Medicine,</i> 10, no. 6 (2014) Elsevier: 1121-1130. https://doi.org/10.1016/j.nano.2014.03.004.en_US
dc.identifier.doihttps://doi.org/10.1016/j.nano.2014.03.004en_US
dc.identifier.urihttps://hdl.handle.net/1911/94861en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordGemcitabineen_US
dc.subject.keywordHepatocellularen_US
dc.subject.keywordHyperthermiaen_US
dc.subject.keywordNanoparticleen_US
dc.subject.keywordRadiofrequencyen_US
dc.titleGold nanoparticles and radiofrequency in experimental models for hepatocellular carcinomaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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