Methods for remote activation and permanent or temporary deactivation of integrated circuits (IC) for digital rights management are disclosed. Remote activation enables designers to remotely control each IC manufactured by an independent silicon foundry. Certain embodiments of the invention exploit inherent unclonable variability in modern manufacturing for the creation of unique identification (ID) and then integrate the IDs into the circuit functionality. Some of the objectives may be realized by replicating a subset of states of one or more finite state machines and by superimposing additional state transitions that are known only to the designer. On each chip, the added transitions signals are a function of the unique IDs and are thus unclonable. The method and system of the invention is robust against operational and environment conditions, unclonable and attack-resilient, while having a low overhead and a unique key for each IC with very high probability.