Quantitative evaluation of in vivo vital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia

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dc.citation.firstpage56002en_US
dc.citation.issueNumber5en_US
dc.citation.journalTitleJournal of Biomedical Opticsen_US
dc.citation.volumeNumber20en_US
dc.contributor.authorThekkek, Nadhien_US
dc.contributor.authorLee, Michelle H.en_US
dc.contributor.authorPolydorides, Alexandros D.en_US
dc.contributor.authorRosen, Daniel G.en_US
dc.contributor.authorAnandasabapathy, Sharmilaen_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.date.accessioned2015-06-30T16:22:57Zen_US
dc.date.available2015-06-30T16:22:57Zen_US
dc.date.issued2015en_US
dc.description.abstractCurrent imaging tools are associated with inconsistent sensitivity and specificity for detection of Barrett’s-associated neoplasia. Optical imaging has shown promise in improving the classification of neoplasia in vivo. The goal of this pilot study was to evaluate whether in vivo vital dye fluorescence imaging (VFI) has the potential to improve the accuracy of early-detection of Barrett’s-associated neoplasia. In vivo endoscopic VFI images were collected from 65 sites in 14 patients with confirmed Barrett’s esophagus (BE), dysplasia, or esophageal adenocarcinoma using a modular video endoscope and a high-resolution microendoscope (HRME). Qualitative image features were compared to histology; VFI and HRME images show changes in glandular structure associated with neoplastic progression. Quantitative image features in VFI images were identified for objective image classification of metaplasia and neoplasia, and a diagnostic algorithm was developed using leave-one-out cross validation. Three image features extracted from VFI images were used to classify tissue as neoplastic or not with a sensitivity of 87.8% and a specificity of 77.6% (AUC=0.878). A multimodal approach incorporating VFI and HRME imaging can delineate epithelial changes present in Barrett’s-associated neoplasia. Quantitative analysis of VFI images may provide a means for objective interpretation of BE during surveillance.en_US
dc.identifier.citationThekkek, Nadhi, Lee, Michelle H., Polydorides, Alexandros D., et al.. "Quantitative evaluation of in vivo vital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia." <i>Journal of Biomedical Optics,</i> 20, no. 5 (2015) SPIE: 56002. http://dx.doi.org/10.1117/1.JBO.20.5.056002.en_US
dc.identifier.doihttp://dx.doi.org/10.1117/1.JBO.20.5.056002en_US
dc.identifier.urihttps://hdl.handle.net/1911/80841en_US
dc.language.isoengen_US
dc.publisherSPIEen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordfluorescence imagingen_US
dc.subject.keywordBarrett's esophagusen_US
dc.subject.keywordendoscopyen_US
dc.subject.keywordesophageal adenocarcinomaen_US
dc.subject.keywordneoplasiaen_US
dc.subject.keywordcontrast agentsen_US
dc.titleQuantitative evaluation of in vivo vital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasiaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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