Fabrication and Mechanical Evaluation of Anatomically-Inspired Quasilaminate Hydrogel Structures with Layer-Specific Formulations

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dc.citation.firstpage398en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitleAnnals of Biomedical Engineeringen_US
dc.citation.lastpage407en_US
dc.citation.volumeNumber41en_US
dc.contributor.authorTseng, Huberten_US
dc.contributor.authorCuchiara, Maude L.en_US
dc.contributor.authorDurst, Christopher A.en_US
dc.contributor.authorCuchiara, Michael P.en_US
dc.contributor.authorLin, Chris J.en_US
dc.contributor.authorWest, Jennifer L.en_US
dc.contributor.authorGrande-Allen, K. Janeen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2013-03-18T20:59:25Zen_US
dc.date.available2014-03-19T05:10:04Zen_US
dc.date.issued2012en_US
dc.description.abstractA major tissue engineering challenge is the creation of multilaminate scaffolds with layer-specific mechanical properties representative of native tissues, such as heart valve leaflets, blood vessels, and cartilage. For this purpose, poly(ethylene glycol) diacrylate (PEGDA) hydrogels are attractive materials due to their tunable mechanical and biological properties. This study explored the fabrication of trilayer hydrogel quasilaminates. A novel sandwich method was devised to create quasilaminates with layers of varying stiffnesses. The trilayer structure was comprised of two "stiff" outer layers and one "soft" inner layer. Tensile testing of bilayer quasilaminates demonstrated that these scaffolds do not fail at the interface. Flexural testing showed that the bending modulus of acellular quasilaminates fell between the bending moduli of the "stiff" and "soft" hydrogel layers. The bending modulus and swelling of trilayer scaffolds with the same formulations were not significantly different than single layer gels of the same formulation. The encapsulation of cells and the addition of phenol red within the hydrogel layers decreased bending modulus of the trilayer scaffolds. The data presented demonstrates that this fabrication method can make quasilaminates with robust interfaces, integrating layers of different mechanical properties and biofunctionalization, and thus forming the foundation for a multilaminate scaffold that more accurately represents native tissue.en_US
dc.embargo.terms1 yearen_US
dc.identifier.citationTseng, Hubert, Cuchiara, Maude L., Durst, Christopher A., et al.. "Fabrication and Mechanical Evaluation of Anatomically-Inspired Quasilaminate Hydrogel Structures with Layer-Specific Formulations." <i>Annals of Biomedical Engineering,</i> 41, no. 2 (2012) Springer: 398-407. http://dx.doi.org/10.1007/s10439-012-0666-5.en_US
dc.identifier.doihttp://dx.doi.org/10.1007/s10439-012-0666-5en_US
dc.identifier.urihttps://hdl.handle.net/1911/70704en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordtissue engineeringen_US
dc.subject.keywordbiomaterialsen_US
dc.subject.keywordhydrogelen_US
dc.subject.keywordlaminateen_US
dc.subject.keywordcompositesen_US
dc.subject.keywordflexureen_US
dc.titleFabrication and Mechanical Evaluation of Anatomically-Inspired Quasilaminate Hydrogel Structures with Layer-Specific Formulationsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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