Fabrication and Mechanical Evaluation of Anatomically-Inspired Quasilaminate Hydrogel Structures with Layer-Specific Formulations

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dc.citation.firstpage398
dc.citation.issueNumber2
dc.citation.journalTitleAnnals of Biomedical Engineering
dc.citation.lastpage407
dc.citation.volumeNumber41
dc.contributor.authorTseng, Hubert
dc.contributor.authorCuchiara, Maude L.
dc.contributor.authorDurst, Christopher A.
dc.contributor.authorCuchiara, Michael P.
dc.contributor.authorLin, Chris J.
dc.contributor.authorWest, Jennifer L.
dc.contributor.authorGrande-Allen, K. Jane
dc.date.accessioned2013-03-18T20:59:25Z
dc.date.available2014-03-19T05:10:04Z
dc.date.issued2012
dc.description.abstractA major tissue engineering challenge is the creation of multilaminate scaffolds with layer-specific mechanical properties representative of native tissues, such as heart valve leaflets, blood vessels, and cartilage. For this purpose, poly(ethylene glycol) diacrylate (PEGDA) hydrogels are attractive materials due to their tunable mechanical and biological properties. This study explored the fabrication of trilayer hydrogel quasilaminates. A novel sandwich method was devised to create quasilaminates with layers of varying stiffnesses. The trilayer structure was comprised of two �stiff� outer layers and one �soft� inner layer. Tensile testing of bilayer quasilaminates demonstrated that these scaffolds do not fail at the interface. Flexural testing showed that the bending modulus of acellular quasilaminates fell between the bending moduli of the �stiff� and �soft� hydrogel layers. The bending modulus and swelling of trilayer scaffolds with the same formulations were not significantly different than single layer gels of the same formulation. The encapsulation of cells and the addition of phenol red within the hydrogel layers decreased bending modulus of the trilayer scaffolds. The data presented demonstrates that this fabrication method can make quasilaminates with robust interfaces, integrating layers of different mechanical properties and biofunctionalization, and thus forming the foundation for a multilaminate scaffold that more accurately represents native tissue.
dc.embargo.terms1 year
dc.identifier.citationTseng, Hubert, Cuchiara, Maude L., Durst, Christopher A., et al.. "Fabrication and Mechanical Evaluation of Anatomically-Inspired Quasilaminate Hydrogel Structures with Layer-Specific Formulations." <i>Annals of Biomedical Engineering,</i> 41, no. 2 (2012) Springer: 398-407. http://dx.doi.org/10.1007/s10439-012-0666-5.
dc.identifier.doihttp://dx.doi.org/10.1007/s10439-012-0666-5
dc.identifier.urihttps://hdl.handle.net/1911/70704
dc.language.isoeng
dc.publisherSpringer
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.subject.keywordtissue engineering
dc.subject.keywordbiomaterials
dc.subject.keywordhydrogel
dc.subject.keywordlaminate
dc.subject.keywordcomposites
dc.subject.keywordflexure
dc.titleFabrication and Mechanical Evaluation of Anatomically-Inspired Quasilaminate Hydrogel Structures with Layer-Specific Formulations
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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