The effects of ER morphology on synaptic structure and function inDrosophila melanogaster

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dc.citation.firstpage1635en_US
dc.citation.journalTitleJournal of Cell Scienceen_US
dc.citation.lastpage1648en_US
dc.citation.volumeNumber129en_US
dc.contributor.authorSummerville, James B.en_US
dc.contributor.authorFaust, Joseph F.en_US
dc.contributor.authorFan, Ethanen_US
dc.contributor.authorPendin, Dianaen_US
dc.contributor.authorDaga, Andreaen_US
dc.contributor.authorFormella, Josephen_US
dc.contributor.authorStern, Michaelen_US
dc.contributor.authorMcNew, James A.en_US
dc.date.accessioned2016-06-06T16:48:22Zen_US
dc.date.available2016-06-06T16:48:22Zen_US
dc.date.issued2016en_US
dc.description.abstractHereditary spastic paraplegia (HSP) is a set of genetic diseases caused by mutations in one of 72 genes that results in age-dependent corticospinal axon degeneration accompanied by spasticity and paralysis. Two genes implicated in HSPs encode proteins that regulate endoplasmic reticulum (ER) morphology. Atlastin 1 (ATL1, also known as SPG3A) encodes an ER membrane fusion GTPase and reticulon 2 (RTN2, also known as SPG12) helps shape ER tube formation. Here, we use a new fluorescent ER marker to show that the ER within wild-type Drosophila motor nerve terminals forms a network of tubules that is fragmented and made diffuse upon loss of the atlastin 1 ortholog atl. atl orRtnl1 loss decreases evoked transmitter release and increases arborization. Similar to other HSP proteins, Atl inhibits bone morphogenetic protein (BMP) signaling, and loss of atl causes age-dependent locomotor deficits in adults. These results demonstrate a crucial role for ER in neuronal function, and identify mechanistic links between ER morphology, neuronal function, BMP signaling and adult behavior.en_US
dc.identifier.citationSummerville, James B., Faust, Joseph F., Fan, Ethan, et al.. "The effects of ER morphology on synaptic structure and function inDrosophila melanogaster." <i>Journal of Cell Science,</i> 129, (2016) The Company of Biologists Ltd: 1635-1648. http://dx.doi.org/10.1242/jcs.184929.en_US
dc.identifier.doihttp://dx.doi.org/10.1242/jcs.184929en_US
dc.identifier.urihttps://hdl.handle.net/1911/90451en_US
dc.language.isoengen_US
dc.publisherThe Company of Biologists Ltden_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordAtlastinen_US
dc.subject.keywordERen_US
dc.subject.keywordReticulonen_US
dc.subject.keywordNeuronen_US
dc.titleThe effects of ER morphology on synaptic structure and function inDrosophila melanogasteren_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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