The effects of ER morphology on synaptic structure and function inDrosophila melanogaster
dc.citation.firstpage | 1635 | |
dc.citation.journalTitle | Journal of Cell Science | |
dc.citation.lastpage | 1648 | |
dc.citation.volumeNumber | 129 | |
dc.contributor.author | Summerville, James B. | |
dc.contributor.author | Faust, Joseph F. | |
dc.contributor.author | Fan, Ethan | |
dc.contributor.author | Pendin, Diana | |
dc.contributor.author | Daga, Andrea | |
dc.contributor.author | Formella, Joseph | |
dc.contributor.author | Stern, Michael | |
dc.contributor.author | McNew, James A. | |
dc.date.accessioned | 2016-06-06T16:48:22Z | |
dc.date.available | 2016-06-06T16:48:22Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Hereditary spastic paraplegia (HSP) is a set of genetic diseases caused by mutations in one of 72 genes that results in age-dependent corticospinal axon degeneration accompanied by spasticity and paralysis. Two genes implicated in HSPs encode proteins that regulate endoplasmic reticulum (ER) morphology. Atlastin 1 (ATL1, also known as SPG3A) encodes an ER membrane fusion GTPase and reticulon 2 (RTN2, also known as SPG12) helps shape ER tube formation. Here, we use a new fluorescent ER marker to show that the ER within wild-type Drosophila motor nerve terminals forms a network of tubules that is fragmented and made diffuse upon loss of the atlastin 1 ortholog atl. atl orRtnl1 loss decreases evoked transmitter release and increases arborization. Similar to other HSP proteins, Atl inhibits bone morphogenetic protein (BMP) signaling, and loss of atl causes age-dependent locomotor deficits in adults. These results demonstrate a crucial role for ER in neuronal function, and identify mechanistic links between ER morphology, neuronal function, BMP signaling and adult behavior. | |
dc.identifier.citation | Summerville, James B., Faust, Joseph F., Fan, Ethan, et al.. "The effects of ER morphology on synaptic structure and function inDrosophila melanogaster." <i>Journal of Cell Science,</i> 129, (2016) The Company of Biologists Ltd: 1635-1648. http://dx.doi.org/10.1242/jcs.184929. | |
dc.identifier.doi | http://dx.doi.org/10.1242/jcs.184929 | |
dc.identifier.uri | https://hdl.handle.net/1911/90451 | |
dc.language.iso | eng | |
dc.publisher | The Company of Biologists Ltd | |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | |
dc.subject.keyword | Atlastin | |
dc.subject.keyword | ER | |
dc.subject.keyword | Reticulon | |
dc.subject.keyword | Neuron | |
dc.title | The effects of ER morphology on synaptic structure and function inDrosophila melanogaster | |
dc.type | Journal article | |
dc.type.dcmi | Text | |
dc.type.publication | publisher version |
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