The effects of ER morphology on synaptic structure and function inDrosophila melanogaster

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dc.citation.firstpage1635
dc.citation.journalTitleJournal of Cell Science
dc.citation.lastpage1648
dc.citation.volumeNumber129
dc.contributor.authorSummerville, James B.
dc.contributor.authorFaust, Joseph F.
dc.contributor.authorFan, Ethan
dc.contributor.authorPendin, Diana
dc.contributor.authorDaga, Andrea
dc.contributor.authorFormella, Joseph
dc.contributor.authorStern, Michael
dc.contributor.authorMcNew, James A.
dc.date.accessioned2016-06-06T16:48:22Z
dc.date.available2016-06-06T16:48:22Z
dc.date.issued2016
dc.description.abstractHereditary spastic paraplegia (HSP) is a set of genetic diseases caused by mutations in one of 72 genes that results in age-dependent corticospinal axon degeneration accompanied by spasticity and paralysis. Two genes implicated in HSPs encode proteins that regulate endoplasmic reticulum (ER) morphology. Atlastin 1 (ATL1, also known as SPG3A) encodes an ER membrane fusion GTPase and reticulon 2 (RTN2, also known as SPG12) helps shape ER tube formation. Here, we use a new fluorescent ER marker to show that the ER within wild-type Drosophila motor nerve terminals forms a network of tubules that is fragmented and made diffuse upon loss of the atlastin 1 ortholog atl. atl orRtnl1 loss decreases evoked transmitter release and increases arborization. Similar to other HSP proteins, Atl inhibits bone morphogenetic protein (BMP) signaling, and loss of atl causes age-dependent locomotor deficits in adults. These results demonstrate a crucial role for ER in neuronal function, and identify mechanistic links between ER morphology, neuronal function, BMP signaling and adult behavior.
dc.identifier.citationSummerville, James B., Faust, Joseph F., Fan, Ethan, et al.. "The effects of ER morphology on synaptic structure and function inDrosophila melanogaster." <i>Journal of Cell Science,</i> 129, (2016) The Company of Biologists Ltd: 1635-1648. http://dx.doi.org/10.1242/jcs.184929.
dc.identifier.doihttp://dx.doi.org/10.1242/jcs.184929
dc.identifier.urihttps://hdl.handle.net/1911/90451
dc.language.isoeng
dc.publisherThe Company of Biologists Ltd
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.subject.keywordAtlastin
dc.subject.keywordER
dc.subject.keywordReticulon
dc.subject.keywordNeuron
dc.titleThe effects of ER morphology on synaptic structure and function inDrosophila melanogaster
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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