A rapid, flexible method for incorporating controlled antibiotic release into porous polymethylmethacrylate space maintainers for craniofacial reconstruction

Simple item page
dc.citation.firstpage121
dc.citation.journalTitleBiomaterials Science
dc.citation.lastpage129
dc.citation.volumeNumber4
dc.contributor.authorMountziaris, Paschalia M.
dc.contributor.authorShah, Sarita R.
dc.contributor.authorLam, Johnny
dc.contributor.authorBennett, George N.
dc.contributor.authorMikos, Antonios G.
dc.date.accessioned2017-05-22T21:48:43Z
dc.date.available2017-05-22T21:48:43Z
dc.date.issued2016
dc.description.abstractSevere injuries in the craniofacial complex, resulting from trauma or pathology, present several challenges to functional and aesthetic reconstruction. The anatomy and position of the craniofacial region make it vulnerable to injury and subsequent local infection due to external bacteria as well as those from neighbouring structures like the sinuses, nasal passages, and mouth. Porous polymethylmethacrylate (PMMA) “space maintainers” have proven useful in staged craniofacial reconstruction by promoting healing of overlying soft tissue prior to reconstruction of craniofacial bones. We describe herein a method by which the porosity of a prefabricated porous PMMA space maintainer, generated by porogen leaching, can be loaded with a thermogelling copolymer-based drug delivery system. Porogen leaching, space maintainer prewetting, and thermogel loading all significantly affected the loading of a model antibiotic, colistin. Weeks-long release of antibiotic at clinically relevant levels was achieved with several formulations. In vitro assays confirmed that the released colistin maintained its antibiotic activity against several bacterial targets. Our results suggest that this method is a valuable tool in the development of novel therapeutic approaches for the treatment of severe complex, infected craniofacial injuries.
dc.identifier.citationMountziaris, Paschalia M., Shah, Sarita R., Lam, Johnny, et al.. "A rapid, flexible method for incorporating controlled antibiotic release into porous polymethylmethacrylate space maintainers for craniofacial reconstruction." <i>Biomaterials Science,</i> 4, (2016) Royal Society of Chemistry: 121-129. http://dx.doi.org/10.1039/C5BM00175G.
dc.identifier.doihttp://dx.doi.org/10.1039/C5BM00175G
dc.identifier.urihttps://hdl.handle.net/1911/94349
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.
dc.titleA rapid, flexible method for incorporating controlled antibiotic release into porous polymethylmethacrylate space maintainers for craniofacial reconstruction
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Rapid-Flexible-Method.pdf
Size:
942.11 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Bioengineering Publications
BioSciences Publications