Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment

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dc.citation.articleNumber016002
dc.citation.issueNumber1
dc.citation.journalTitleJournal of Biomedical Optics
dc.citation.volumeNumber28
dc.contributor.authorCoole, Jackson B.
dc.contributor.authorBrenes, David R.
dc.contributor.authorMitbander, Ruchika
dc.contributor.authorVohra, Imran S.
dc.contributor.authorHou, Huayu
dc.contributor.authorKortum, Alex
dc.contributor.authorTang, Yubo
dc.contributor.authorMaker, Yajur
dc.contributor.authorSchwarz, Richard A.
dc.contributor.authorCarns, Jennifer L.
dc.contributor.authorBadaoui, Hawraa
dc.contributor.authorWilliams, Michelle D.
dc.contributor.authorVigneswaran, Nadarajah
dc.contributor.authorGillenwater, Ann M.
dc.contributor.authorRichards-Kortum, Rebecca
dc.date.accessioned2023-02-23T18:46:08Z
dc.date.available2023-02-23T18:46:08Z
dc.date.issued2023
dc.description.abstractSignificance: Despite recent advances in multimodal optical imaging, oral imaging systems often do not provide real-time actionable guidance to the clinician who is making biopsy and treatment decisions. Aim: We demonstrate a low-cost, portable active biopsy guidance system (ABGS) that uses multimodal optical imaging with deep learning to directly project cancer risk and biopsy guidance maps onto oral mucosa in real time. Approach: Cancer risk maps are generated based on widefield autofluorescence images and projected onto the at-risk tissue using a digital light projector. Microendoscopy images are obtained from at-risk areas, and multimodal image data are used to calculate a biopsy guidance map, which is projected onto tissue.ResultsRepresentative patient examples highlight clinically actionable visualizations provided in real time during an imaging procedure. Results show multimodal imaging with cancer risk and biopsy guidance map projection offers a versatile, quantitative, and precise tool to guide biopsy site selection and improve early detection of oral cancers. Conclusions: The ABGS provides direct visible guidance to identify early lesions and locate appropriate sites to biopsy within those lesions. This represents an opportunity to translate multimodal imaging into real-time clinically actionable visualizations to help improve patient outcomes.
dc.identifier.citationCoole, Jackson B., Brenes, David R., Mitbander, Ruchika, et al.. "Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment." <i>Journal of Biomedical Optics,</i> 28, no. 1 (2023) SPIE: https://doi.org/10.1117/1.JBO.28.1.016002.
dc.identifier.digital016002_1
dc.identifier.doihttps://doi.org/10.1117/1.JBO.28.1.016002
dc.identifier.urihttps://hdl.handle.net/1911/114468
dc.language.isoeng
dc.publisherSPIE
dc.rightsPublished by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMultimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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