Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment

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dc.citation.articleNumber016002en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitleJournal of Biomedical Opticsen_US
dc.citation.volumeNumber28en_US
dc.contributor.authorCoole, Jackson B.en_US
dc.contributor.authorBrenes, David R.en_US
dc.contributor.authorMitbander, Ruchikaen_US
dc.contributor.authorVohra, Imran S.en_US
dc.contributor.authorHou, Huayuen_US
dc.contributor.authorKortum, Alexen_US
dc.contributor.authorTang, Yuboen_US
dc.contributor.authorMaker, Yajuren_US
dc.contributor.authorSchwarz, Richard A.en_US
dc.contributor.authorCarns, Jennifer L.en_US
dc.contributor.authorBadaoui, Hawraaen_US
dc.contributor.authorWilliams, Michelle D.en_US
dc.contributor.authorVigneswaran, Nadarajahen_US
dc.contributor.authorGillenwater, Ann M.en_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2023-02-23T18:46:08Zen_US
dc.date.available2023-02-23T18:46:08Zen_US
dc.date.issued2023en_US
dc.description.abstractSignificance: Despite recent advances in multimodal optical imaging, oral imaging systems often do not provide real-time actionable guidance to the clinician who is making biopsy and treatment decisions. Aim: We demonstrate a low-cost, portable active biopsy guidance system (ABGS) that uses multimodal optical imaging with deep learning to directly project cancer risk and biopsy guidance maps onto oral mucosa in real time. Approach: Cancer risk maps are generated based on widefield autofluorescence images and projected onto the at-risk tissue using a digital light projector. Microendoscopy images are obtained from at-risk areas, and multimodal image data are used to calculate a biopsy guidance map, which is projected onto tissue.ResultsRepresentative patient examples highlight clinically actionable visualizations provided in real time during an imaging procedure. Results show multimodal imaging with cancer risk and biopsy guidance map projection offers a versatile, quantitative, and precise tool to guide biopsy site selection and improve early detection of oral cancers. Conclusions: The ABGS provides direct visible guidance to identify early lesions and locate appropriate sites to biopsy within those lesions. This represents an opportunity to translate multimodal imaging into real-time clinically actionable visualizations to help improve patient outcomes.en_US
dc.identifier.citationCoole, Jackson B., Brenes, David R., Mitbander, Ruchika, et al.. "Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment." <i>Journal of Biomedical Optics,</i> 28, no. 1 (2023) SPIE: https://doi.org/10.1117/1.JBO.28.1.016002.en_US
dc.identifier.digital016002_1en_US
dc.identifier.doihttps://doi.org/10.1117/1.JBO.28.1.016002en_US
dc.identifier.urihttps://hdl.handle.net/1911/114468en_US
dc.language.isoengen_US
dc.publisherSPIEen_US
dc.rightsPublished by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleMultimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatmenten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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