Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects

Simple item page
dc.citation.articleNumber1217054en_US
dc.citation.journalTitleFrontiers in Agingen_US
dc.citation.volumeNumber4en_US
dc.contributor.authorAwad, Kamalen_US
dc.contributor.authorAhuja, Neelamen_US
dc.contributor.authorYacoub, Ahmed S.en_US
dc.contributor.authorBrotto, Leticiaen_US
dc.contributor.authorYoung, Simonen_US
dc.contributor.authorMikos, Antoniosen_US
dc.contributor.authorAswath, Praneshen_US
dc.contributor.authorVaranasi, Venuen_US
dc.date.accessioned2024-05-03T15:51:10Zen_US
dc.date.available2024-05-03T15:51:10Zen_US
dc.date.issued2023en_US
dc.description.abstractIn this review, we explore the application of novel biomaterial-based therapies specifically targeted towards craniofacial bone defects. The repair and regeneration of critical sized bone defects in the craniofacial region requires the use of bioactive materials to stabilize and expedite the healing process. However, the existing clinical approaches face challenges in effectively treating complex craniofacial bone defects, including issues such as oxidative stress, inflammation, and soft tissue loss. Given that a significant portion of individuals affected by traumatic bone defects in the craniofacial area belong to the aging population, there is an urgent need for innovative biomaterials to address the declining rate of new bone formation associated with age-related changes in the skeletal system. This article emphasizes the importance of semiconductor industry-derived materials as a potential solution to combat oxidative stress and address the challenges associated with aging bone. Furthermore, we discuss various material and autologous treatment approaches, as well as in vitro and in vivo models used to investigate new therapeutic strategies in the context of craniofacial bone repair. By focusing on these aspects, we aim to shed light on the potential of advanced biomaterials to overcome the limitations of current treatments and pave the way for more effective and efficient therapeutic interventions for craniofacial bone defects.en_US
dc.identifier.citationAwad, K., Ahuja, N., Yacoub, A. S., Brotto, L., Young, S., Mikos, A., Aswath, P., & Varanasi, V. (2023). Revolutionizing bone regeneration: Advanced biomaterials for healing compromised bone defects. Frontiers in Aging, 4. https://doi.org/10.3389/fragi.2023.1217054en_US
dc.identifier.digitalfragi-04-1217054en_US
dc.identifier.doihttps://doi.org/10.3389/fragi.2023.1217054en_US
dc.identifier.urihttps://hdl.handle.net/1911/115550en_US
dc.language.isoengen_US
dc.publisherFrontiers Media S.A.en_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleRevolutionizing bone regeneration: advanced biomaterials for healing compromised bone defectsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
fragi-04-1217054.pdf
Size:
2.63 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Bioengineering Publications