Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects

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dc.citation.articleNumber1217054
dc.citation.journalTitleFrontiers in Aging
dc.citation.volumeNumber4
dc.contributor.authorAwad, Kamal
dc.contributor.authorAhuja, Neelam
dc.contributor.authorYacoub, Ahmed S.
dc.contributor.authorBrotto, Leticia
dc.contributor.authorYoung, Simon
dc.contributor.authorMikos, Antonios
dc.contributor.authorAswath, Pranesh
dc.contributor.authorVaranasi, Venu
dc.date.accessioned2024-05-03T15:51:10Z
dc.date.available2024-05-03T15:51:10Z
dc.date.issued2023
dc.description.abstractIn this review, we explore the application of novel biomaterial-based therapies specifically targeted towards craniofacial bone defects. The repair and regeneration of critical sized bone defects in the craniofacial region requires the use of bioactive materials to stabilize and expedite the healing process. However, the existing clinical approaches face challenges in effectively treating complex craniofacial bone defects, including issues such as oxidative stress, inflammation, and soft tissue loss. Given that a significant portion of individuals affected by traumatic bone defects in the craniofacial area belong to the aging population, there is an urgent need for innovative biomaterials to address the declining rate of new bone formation associated with age-related changes in the skeletal system. This article emphasizes the importance of semiconductor industry-derived materials as a potential solution to combat oxidative stress and address the challenges associated with aging bone. Furthermore, we discuss various material and autologous treatment approaches, as well as in vitro and in vivo models used to investigate new therapeutic strategies in the context of craniofacial bone repair. By focusing on these aspects, we aim to shed light on the potential of advanced biomaterials to overcome the limitations of current treatments and pave the way for more effective and efficient therapeutic interventions for craniofacial bone defects.
dc.identifier.citationAwad, K., Ahuja, N., Yacoub, A. S., Brotto, L., Young, S., Mikos, A., Aswath, P., & Varanasi, V. (2023). Revolutionizing bone regeneration: Advanced biomaterials for healing compromised bone defects. Frontiers in Aging, 4. https://doi.org/10.3389/fragi.2023.1217054
dc.identifier.digitalfragi-04-1217054
dc.identifier.doihttps://doi.org/10.3389/fragi.2023.1217054
dc.identifier.urihttps://hdl.handle.net/1911/115550
dc.language.isoeng
dc.publisherFrontiers Media S.A.
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleRevolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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