Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model

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dc.citation.firstpage8832en_US
dc.citation.issueNumber11en_US
dc.citation.journalTitleActa Biomaterialiaen_US
dc.citation.lastpage8839en_US
dc.citation.volumeNumber9en_US
dc.contributor.authorSpicer, Patrick P.en_US
dc.contributor.authorShah, Sarita R.en_US
dc.contributor.authorHenslee, Allan M.en_US
dc.contributor.authorWatson, Brendan M.en_US
dc.contributor.authorKinard, Lucas A.en_US
dc.contributor.authorKretlow, James D.en_US
dc.contributor.authorBevil, Kristinen_US
dc.contributor.authorKattchee, Laurenen_US
dc.contributor.authorBennett, George N.en_US
dc.contributor.authorDemian, Nagi M.en_US
dc.contributor.authorMende, Katrinen_US
dc.contributor.authorMurray, Clinton K.en_US
dc.contributor.authorJansen, John A.en_US
dc.contributor.authorWong, Mark E.en_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.authorKasper, F.Kurtisen_US
dc.date.accessioned2014-03-12T21:47:26Zen_US
dc.date.available2014-03-12T21:47:26Zen_US
dc.date.issued2013-11en_US
dc.description.abstractThis study evaluated the in vitro and in vivo performance of antibiotic-releasing porous polymethylmethacrylate (PMMA)-based space maintainers comprising a gelatin hydrogel porogen and a poly(DL-lactic-co-glycolic acid) (PLGA) particulate carrier for antibiotic delivery. Colistin was released in vitro from either gelatin or PLGA microparticle loaded PMMA constructs, with gelatin-loaded constructs releasing colistin over approximately 7 days and PLGA microparticle-loaded constructs releasing colistin up to 8 weeks. Three formulations with either a burst release or extended release in different doses were tested in a rabbit mandibular defect inoculated with Acinetobacter baumannii (2 × 107 colony forming units/mL). In addition, one material control that released antibiotic but was not inoculated with A. baumannii was tested. A. baumannii was not detectable in any animal after 12 weeks by culture of the defect, saliva, or blood. Defects with high-dose, extended-release implants had greater soft tissue healing compared to defects with burst release implants, with 8 out of 10 animals showing healed mucosae compared to 2 out of 10 with healed mucosae, respectively. Extended release of locally delivered colistin via a PLGA microparticle carrier improved soft tissue healing over the implants compared to burst release of colistin from a gelatin carrier.en_US
dc.identifier.citationSpicer, Patrick P., Shah, Sarita R., Henslee, Allan M., et al.. "Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model." <i>Acta Biomaterialia,</i> 9, no. 11 (2013) Elsevier: 8832-8839. http://dx.doi.org/10.1016/j.actbio.2013.07.018.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.actbio.2013.07.018en_US
dc.identifier.urihttps://hdl.handle.net/1911/75577en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordspace maintaineren_US
dc.subject.keywordcraniofacial reconstructionen_US
dc.subject.keywordantibiotic deliveryen_US
dc.subject.keywordinfected defecten_US
dc.subject.keywordcomposite tissue defecten_US
dc.titleEvaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect modelen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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