Moving beyond static snapshots: Protein dynamics and the Protein Data Bank

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dc.citation.articleNumber100749en_US
dc.citation.journalTitleJournal of Biological Chemistryen_US
dc.citation.volumeNumber296en_US
dc.contributor.authorMiller, Mitchell D.en_US
dc.contributor.authorPhillips, George N.Jr.en_US
dc.date.accessioned2021-06-10T17:36:45Zen_US
dc.date.available2021-06-10T17:36:45Zen_US
dc.date.issued2021en_US
dc.description.abstractProteins are the molecular machines of living systems. Their dynamics are an intrinsic part of their evolutionary selection in carrying out their biological functions. Although the dynamics are more difficult to observe than a static, average structure, we are beginning to observe these dynamics and form sound mechanistic connections between structure, dynamics, and function. This progress is highlighted in case studies from myoglobin and adenylate kinase to the ribosome and molecular motors where these molecules are being probed with a multitude of techniques across many timescales. New approaches to time-resolved crystallography are allowing simple “movies” to be taken of proteins in action, and new methods of mapping the variations in cryo-electron microscopy are emerging to reveal a more complete description of life’s machines. The results of these new methods are aided in their dissemination by continual improvements in curation and distribution by the Protein Data Bank and their partners around the world.en_US
dc.identifier.citationMiller, Mitchell D. and Phillips, George N.Jr.. "Moving beyond static snapshots: Protein dynamics and the Protein Data Bank." <i>Journal of Biological Chemistry,</i> 296, (2021) Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology: https://doi.org/10.1016/j.jbc.2021.100749.en_US
dc.identifier.digital1-s2-0-S0021925821005391-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.jbc.2021.100749en_US
dc.identifier.urihttps://hdl.handle.net/1911/110707en_US
dc.language.isoengen_US
dc.publisherElsevier Inc on behalf of American Society for Biochemistry and Molecular Biologyen_US
dc.rightsThis is an open access article under the CC BY licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleMoving beyond static snapshots: Protein dynamics and the Protein Data Banken_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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