Moving beyond static snapshots: Protein dynamics and the Protein Data Bank

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dc.citation.articleNumber100749
dc.citation.journalTitleJournal of Biological Chemistry
dc.citation.volumeNumber296
dc.contributor.authorMiller, Mitchell D.
dc.contributor.authorPhillips, George N.Jr.
dc.date.accessioned2021-06-10T17:36:45Z
dc.date.available2021-06-10T17:36:45Z
dc.date.issued2021
dc.description.abstractProteins are the molecular machines of living systems. Their dynamics are an intrinsic part of their evolutionary selection in carrying out their biological functions. Although the dynamics are more difficult to observe than a static, average structure, we are beginning to observe these dynamics and form sound mechanistic connections between structure, dynamics, and function. This progress is highlighted in case studies from myoglobin and adenylate kinase to the ribosome and molecular motors where these molecules are being probed with a multitude of techniques across many timescales. New approaches to time-resolved crystallography are allowing simple “movies” to be taken of proteins in action, and new methods of mapping the variations in cryo-electron microscopy are emerging to reveal a more complete description of life’s machines. The results of these new methods are aided in their dissemination by continual improvements in curation and distribution by the Protein Data Bank and their partners around the world.
dc.identifier.citationMiller, Mitchell D. and Phillips, George N.Jr.. "Moving beyond static snapshots: Protein dynamics and the Protein Data Bank." <i>Journal of Biological Chemistry,</i> 296, (2021) Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology: https://doi.org/10.1016/j.jbc.2021.100749.
dc.identifier.digital1-s2-0-S0021925821005391-main
dc.identifier.doihttps://doi.org/10.1016/j.jbc.2021.100749
dc.identifier.urihttps://hdl.handle.net/1911/110707
dc.language.isoeng
dc.publisherElsevier Inc on behalf of American Society for Biochemistry and Molecular Biology
dc.rightsThis is an open access article under the CC BY license
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMoving beyond static snapshots: Protein dynamics and the Protein Data Bank
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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