Learning to express reward prediction error-like dopaminergic activity requires plastic representations of time

dc.citation.articleNumber5856en_US
dc.citation.journalTitleNature Communicationsen_US
dc.citation.volumeNumber15en_US
dc.contributor.authorCone, Ianen_US
dc.contributor.authorClopath, Claudiaen_US
dc.contributor.authorShouval, Harel Z.en_US
dc.date.accessioned2024-08-09T16:25:26Zen_US
dc.date.available2024-08-09T16:25:26Zen_US
dc.date.issued2024en_US
dc.description.abstractThe dominant theoretical framework to account for reinforcement learning in the brain is temporal difference learning (TD) learning, whereby certain units signal reward prediction errors (RPE). The TD algorithm has been traditionally mapped onto the dopaminergic system, as firing properties of dopamine neurons can resemble RPEs. However, certain predictions of TD learning are inconsistent with experimental results, and previous implementations of the algorithm have made unscalable assumptions regarding stimulus-specific fixed temporal bases. We propose an alternate framework to describe dopamine signaling in the brain, FLEX (Flexibly Learned Errors in Expected Reward). In FLEX, dopamine release is similar, but not identical to RPE, leading to predictions that contrast to those of TD. While FLEX itself is a general theoretical framework, we describe a specific, biophysically plausible implementation, the results of which are consistent with a preponderance of both existing and reanalyzed experimental data.en_US
dc.identifier.citationCone, I., Clopath, C., & Shouval, H. Z. (2024). Learning to express reward prediction error-like dopaminergic activity requires plastic representations of time. Nature Communications, 15(1), 5856. https://doi.org/10.1038/s41467-024-50205-3en_US
dc.identifier.digitals41467-024-50205-3en_US
dc.identifier.doihttps://doi.org/10.1038/s41467-024-50205-3en_US
dc.identifier.urihttps://hdl.handle.net/1911/117642en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleLearning to express reward prediction error-like dopaminergic activity requires plastic representations of timeen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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