Stochastic dynamics of genetic broadcasting networks
| dc.citation.articleNumber | 052305 | |
| dc.citation.issueNumber | 5 | |
| dc.citation.journalTitle | Physical Review E | |
| dc.citation.volumeNumber | 96 | |
| dc.contributor.author | Potoyan, Davit A. | |
| dc.contributor.author | Wolynes, Peter G. | |
| dc.contributor.org | Center for Theoretical Biological Physics | |
| dc.date.accessioned | 2017-12-21T18:21:53Z | |
| dc.date.available | 2017-12-21T18:21:53Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | The complex genetic programs of eukaryotic cells are often regulated by key transcription factors occupying or clearing out of a large number of genomic locations. Orchestrating the residence times of these factors is therefore important for the well organized functioning of a large network. The classic models of genetic switches sidestep this timing issue by assuming the binding of transcription factors to be governed entirely by thermodynamic protein-DNA affinities. Here we show that relying on passive thermodynamics and random release times can lead to a “time-scale crisis” for master genes that broadcast their signals to a large number of binding sites. We demonstrate that this time-scale crisis for clearance in a large broadcasting network can be resolved by actively regulating residence times through molecular stripping. We illustrate these ideas by studying a model of the stochastic dynamics of the genetic network of the central eukaryotic master regulator NFκB which broadcasts its signals to many downstream genes that regulate immune response, apoptosis, etc. | |
| dc.identifier.citation | Potoyan, Davit A. and Wolynes, Peter G.. "Stochastic dynamics of genetic broadcasting networks." <i>Physical Review E,</i> 96, no. 5 (2017) American Physical Society: https://doi.org/10.1103/PhysRevE.96.052305. | |
| dc.identifier.digital | PhysRevE-96-052305 | |
| dc.identifier.doi | https://doi.org/10.1103/PhysRevE.96.052305 | |
| dc.identifier.uri | https://hdl.handle.net/1911/98917 | |
| dc.language.iso | eng | |
| dc.publisher | American Physical Society | |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | |
| dc.title | Stochastic dynamics of genetic broadcasting networks | |
| dc.type | Journal article | |
| dc.type.dcmi | Text | |
| dc.type.publication | publisher version |
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