Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity

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dc.citation.articleNumber109009en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleCell Reportsen_US
dc.citation.volumeNumber35en_US
dc.contributor.authorBota-Rabassedas, Neusen_US
dc.contributor.authorBanerjee, Priyamen_US
dc.contributor.authorNiu, Yichien_US
dc.contributor.authorCao, Wenjianen_US
dc.contributor.authorLuo, Jiayien_US
dc.contributor.authorXi, Yuanxinen_US
dc.contributor.authorTan, Xiaochaoen_US
dc.contributor.authorSheng, Kuanweien_US
dc.contributor.authorAhn, Young-Hoen_US
dc.contributor.authorLee, Sieunen_US
dc.contributor.authorParra, Edwin Rogeren_US
dc.contributor.authorRodriguez-Canales, Jaimeen_US
dc.contributor.authorAlbritton, Jacoben_US
dc.contributor.authorWeiger, Michaelen_US
dc.contributor.authorLiu, Xinen_US
dc.contributor.authorGuo, Hou-Fuen_US
dc.contributor.authorYu, Jiangen_US
dc.contributor.authorRodriguez, B. Leticiaen_US
dc.contributor.authorFirestone, Joshua J.A.en_US
dc.contributor.authorMino, Barbaraen_US
dc.contributor.authorCreighton, Chad J.en_US
dc.contributor.authorSolis, Luisa M.en_US
dc.contributor.authorVillalobos, Pamelaen_US
dc.contributor.authorRaso, Maria Gabrielaen_US
dc.contributor.authorSazer, Daniel W.en_US
dc.contributor.authorGibbons, Don L.en_US
dc.contributor.authorRussell, William K.en_US
dc.contributor.authorLongmore, Gregory D.en_US
dc.contributor.authorWistuba, Ignacio I.en_US
dc.contributor.authorWang, Jingen_US
dc.contributor.authorChapman, Harold A.en_US
dc.contributor.authorMiller, Jordan S.en_US
dc.contributor.authorZong, Chenghangen_US
dc.contributor.authorKurie, Jonathan M.en_US
dc.date.accessioned2021-05-07T19:23:39Zen_US
dc.date.available2021-05-07T19:23:39Zen_US
dc.date.issued2021en_US
dc.description.abstractCancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. The EMT, in turn, sensitizes LUAD cells to pro-metastatic signals from CAFs. Thus, CAFs respond to contextual cues from LUAD cells to promote metastasis.en_US
dc.identifier.citationBota-Rabassedas, Neus, Banerjee, Priyam, Niu, Yichi, et al.. "Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity." <i>Cell Reports,</i> 35, no. 3 (2021) Cell Press: https://doi.org/10.1016/j.celrep.2021.109009.en_US
dc.identifier.digital1-s2-0-S2211124721003235-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2021.109009en_US
dc.identifier.urihttps://hdl.handle.net/1911/110487en_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.titleContextual cues from cancer cells govern cancer-associated fibroblast heterogeneityen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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