Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report

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dc.citation.firstpage1308en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitlePhotochemistry and Photobiologyen_US
dc.citation.lastpage1313en_US
dc.citation.volumeNumber94en_US
dc.contributor.authorPantano, Naitielleen_US
dc.contributor.authorHunt, Bradyen_US
dc.contributor.authorSchwarz, Richard A.en_US
dc.contributor.authorParra, Soniaen_US
dc.contributor.authorCherry, Katelinen_US
dc.contributor.authorPossati‐Resende, Júlio Césaren_US
dc.contributor.authorLongatto‐Filho, Adhemaren_US
dc.contributor.authorFregnani, José Humberto Tavares Guerreiroen_US
dc.contributor.authorCastle, Philip E.en_US
dc.contributor.authorSchmeler, Kathleenen_US
dc.contributor.authorRichards‐Kortum, Rebeccaen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2019-01-09T17:21:10Zen_US
dc.date.available2019-01-09T17:21:10Zen_US
dc.date.issued2018en_US
dc.description.abstractProflavine is an acridine dye used with high-resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short-term exposure of cervical tissue to dilute proflavine may increase cervical cancer risk. We performed a retrospective analysis of women referred for colposcopy to Barretos Cancer Hospital comparing the risk of cervical disease progression in those whose cervical tissue was (n = 232) or was not exposed (n = 160) to proflavine. Patients in both groups underwent treatment and follow-up based on histopathologic results and per the local standards of care. Progression of disease was evaluated by comparing histopathology from the initial visit to the worst subsequent histopathology result from all follow-up visits. Mean duration of follow-up was 18.7 and 20.1 months for the proflavine-exposed and controls groups, respectively. There were no significant differences in disease progression from normal/CIN1 to CIN2/3 or from any initial diagnosis to invasive cancer between the proflavine exposed and control groups overall. Risks of cervical dysplasia progression observed in this study are in agreement with those of the natural history of cervical cancer. Our results suggest that cervical exposure to dilute proflavine does not increase the risk of cervical precancer and cancer.en_US
dc.identifier.citationPantano, Naitielle, Hunt, Brady, Schwarz, Richard A., et al.. "Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report." <i>Photochemistry and Photobiology,</i> 94, no. 6 (2018) Wiley: 1308-1313. https://doi.org/10.1111/php.12976.en_US
dc.identifier.digitalProflavine-Exposureen_US
dc.identifier.doihttps://doi.org/10.1111/php.12976en_US
dc.identifier.urihttps://hdl.handle.net/1911/105024en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleIs Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Reporten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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