Construction of an Effective Landscape for Multistate Genetic Switches

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dc.citation.firstpage78102en_US
dc.citation.journalTitlePhysical Review Lettersen_US
dc.citation.volumeNumber113en_US
dc.contributor.authorLu, Mingyangen_US
dc.contributor.authorOnuchic, Joséen_US
dc.contributor.authorBen-Jacob, Eshelen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2014-09-30T16:31:17Z
dc.date.available2014-09-30T16:31:17Z
dc.date.issued2014en_US
dc.description.abstractMultistate genetic switches play a crucial role during embryonic development and tumorigenesis. An archetypical example is the three-way switch regulating epithelial-hybrid-mesenchymal transitions. We devise a special WKB-based approach to investigate white Gaussian and shot noise effects on three-way switches, and construct an effective landscape in good quantitative agreement with stochastic simulations. This approach allows efficient analytical or numerical calculation of the landscape contours, the optimal path, and the state relative stability for general multicomponent multistate switches.en_US
dc.identifier.citationLu, Mingyang, Onuchic, José and Ben-Jacob, Eshel. "Construction of an Effective Landscape for Multistate Genetic Switches." <i>Physical Review Letters,</i> 113, (2014) American Physical Society: 78102. http://dx.doi.org/10.1103/PhysRevLett.113.078102.
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevLett.113.078102en_US
dc.identifier.urihttps://hdl.handle.net/1911/77317
dc.language.isoengen_US
dc.publisherAmerican Physical Society
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titleConstruction of an Effective Landscape for Multistate Genetic Switchesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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