Hierarchy in gene expression is predictive of risk, progression, and outcome in adult acute myeloid leukemia

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dc.citation.firstpage16016
dc.citation.issueNumber1
dc.citation.journalTitlePhysical Biology
dc.citation.volumeNumber12
dc.contributor.authorTripathi, Shubham
dc.contributor.authorDeem, Michael W.
dc.date.accessioned2015-03-19T15:07:12Z
dc.date.available2015-03-19T15:07:12Z
dc.date.issued2015
dc.description.abstractCancer progresses with a change in the structure of the gene network in normal cells. We define a measure of organizational hierarchy in gene networks of affected cells in adult acute myeloid leukemia (AML) patients. With a retrospective cohort analysis based on the gene expression profiles of 116 AML patients, we find that the likelihood of future cancer relapse and the level of clinical risk are directly correlated with the level of organization in the cancer related gene network. We also explore the variation of the level of organization in the gene network with cancer progression. We find that this variation is non-monotonic, which implies the fitness landscape in the evolution of AML cancer cells is non-trivial. We further find that the hierarchy in gene expression at the time of diagnosis may be a useful biomarker in AML prognosis.
dc.identifier.citationTripathi, Shubham and Deem, Michael W.. "Hierarchy in gene expression is predictive of risk, progression, and outcome in adult acute myeloid leukemia." <i>Physical Biology,</i> 12, no. 1 (2015) IOP Publishing: 16016. http://dx.doi.org/10.1088/1478-3975/12/1/016016.
dc.identifier.doihttp://dx.doi.org/10.1088/1478-3975/12/1/016016
dc.identifier.urihttps://hdl.handle.net/1911/79387
dc.language.isoeng
dc.publisherIOP Publishing
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing.
dc.subject.keywordAML
dc.subject.keywordcancer progression
dc.subject.keywordcancer genes
dc.subject.keywordcancer network
dc.titleHierarchy in gene expression is predictive of risk, progression, and outcome in adult acute myeloid leukemia
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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