Influence of size and crystallinity of nanohydroxyapatite (nHA) particles on the properties of Polylactic Acid/nHA nanocomposite scaffolds produced by 3D printing

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dc.citation.firstpage3101
dc.citation.journalTitleJournal of Materials Research and Technology
dc.citation.lastpage3111
dc.citation.volumeNumber30
dc.contributor.authorRodovalho, Arthur João Reis Lima
dc.contributor.authorBarbosa, Willams Teles
dc.contributor.authorVieira, Jaqueline Leite
dc.contributor.authorOliva, Caio Athayde de
dc.contributor.authorGonçalves, Ana Paula Bispo
dc.contributor.authorCardoso, Pollyana da Silva Melo
dc.contributor.authorModolon, Henrique Borba
dc.contributor.authorMontedo, Oscar Rubem Klegues
dc.contributor.authorArcaro, Sabrina
dc.contributor.authorHodel, Katharine Valéria Saraiva
dc.contributor.authorSoares, Milena Botelho Pereira
dc.contributor.authorAjayan, Pulickel M.
dc.contributor.authorBarbosa, Josiane Dantas Viana
dc.date.accessioned2024-07-25T20:55:14Z
dc.date.available2024-07-25T20:55:14Z
dc.date.issued2024
dc.description.abstractPolylactic acid (PLA) and hydroxyapatite (HA) composite scaffolds have been widely studied for applications in bone tissue engineering (BTE) due to their bioactive and biocompatible properties. However, there is a need for more knowledge about the influence of size and crystallinity of HA nanoparticles (nHA) on the properties of PLA/nHA nanocomposite scaffolds produced by 3D printing. In this study, 3D printing was used to produce PLA nanocomposite scaffolds incorporated with nHA filler with different particle sizes and crystallinities. Initially, the nanocomposites were prepared by casting for 3D printing of scaffolds, which were characterized by analysis of thermal, morphological, physical-chemical, mechanical, and biological properties in vitro. The results showed that the size and crystallinity of nHA particles mainly influenced the scaffolds' mechanical properties, degradation rate, and bioactivity. Incorporating nHA provided a gain in compressive strength compared to pure PLA, superior to natural cancellous bone, which varies between 2 and 12 MPa. The lower crystallinity, 39.46 %, promoted a higher rate of degradation and bioactivity in vitro due to its solubility in the simulated fluid. All nanocomposite scaffolds showed cell viability above 90 %. The scaffolds showed suitable properties for BTE applications.
dc.identifier.citationRodovalho, A. J. R. L., Barbosa, W. T., Vieira, J. L., Oliva, C. A. de, Gonçalves, A. P. B., Cardoso, P. da S. M., Modolon, H. B., Montedo, O. R. K., Arcaro, S., Hodel, K. V. S., Soares, M. B. P., Ajayan, P. M., & Barbosa, J. D. V. (2024). Influence of size and crystallinity of nanohydroxyapatite (nHA) particles on the properties of Polylactic Acid/nHA nanocomposite scaffolds produced by 3D printing. Journal of Materials Research and Technology, 30, 3101–3111. https://doi.org/10.1016/j.jmrt.2024.04.048
dc.identifier.digital1-s20-S2238785424008226-main
dc.identifier.doihttps://doi.org/10.1016/j.jmrt.2024.04.048
dc.identifier.urihttps://hdl.handle.net/1911/117485
dc.language.isoeng
dc.publisherElsevier
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleInfluence of size and crystallinity of nanohydroxyapatite (nHA) particles on the properties of Polylactic Acid/nHA nanocomposite scaffolds produced by 3D printing
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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