Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment

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dc.citation.firstpage12728en_US
dc.citation.journalTitleNanoscaleen_US
dc.citation.lastpage12736en_US
dc.citation.volumeNumber7en_US
dc.contributor.authorQuinto, Christopher A.en_US
dc.contributor.authorMohindra, Priyaen_US
dc.contributor.authorTong, Shengen_US
dc.contributor.authorBao, Gangen_US
dc.date.accessioned2017-06-14T18:46:24Zen_US
dc.date.available2017-06-14T18:46:24Zen_US
dc.date.issued2015en_US
dc.description.abstractSuperparamagnetic iron oxide (SPIO) nanoparticles have the potential for use as a multimodal cancer therapy agent due to their ability to carry anticancer drugs and generate localized heat when exposed to an alternating magnetic field, resulting in combined chemotherapy and hyperthermia. To explore this potential, we synthesized SPIOs with a phospholipid-polyethylene glycol (PEG) coating, and loaded Doxorubicin (DOX) with a 30.8% w/w loading capacity when the PEG length is optimized. We found that DOX-loaded SPIOs exhibited a sustained DOX release over 72 hours where the release kinetics could be altered by the PEG length. In contrast, the heating efficiency of the SPIOs showed minimal change with the PEG length. With a core size of 14 nm, the SPIOs could generate sufficient heat to raise the local temperature to 43 °C, sufficient to trigger apoptosis in cancer cells. Further, we found that DOX-loaded SPIOs resulted in cell death comparable to free DOX, and that the combined effect of DOX and SPIO-induced hyperthermia enhanced cancer cell death in vitro. This study demonstrates the potential of using phospholipid-PEG coated SPIOs for chemotherapy–hyperthermia combinatorial cancer treatment with increased efficacy.en_US
dc.identifier.citationQuinto, Christopher A., Mohindra, Priya, Tong, Sheng, et al.. "Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment." <i>Nanoscale,</i> 7, (2015) Royal Society of Chemistry: 12728-12736. https://doi.org/10.1039/C5NR02718G.en_US
dc.identifier.doihttps://doi.org/10.1039/C5NR02718Gen_US
dc.identifier.urihttps://hdl.handle.net/1911/94845en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.en_US
dc.titleMultifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatmenten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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