Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth

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dc.contributor.assigneeRice Universityeng
dc.contributor.publisherUnited States Patent and Trademark Officeeng
dc.creatorAmbrose, Catherine G.eng
dc.creatorClyburn, Terry A.eng
dc.creatorMikos, Antonio G.eng
dc.date.accessioned2015-12-18T17:47:04Z
dc.date.available2015-12-18T17:47:04Z
dc.date.filed2008-12-10
dc.date.issued2015-03-24
dc.description.abstractA method of treating or preventing infection at a surgical site comprising a bony defect and an implanted metal device is disclosed. Biodegradable microspheres are placed at the site and are capable of near-linear controlled release of an antibiotic agent for a predetermined period of time. The microspheres are configured to be large enough to avoid being phagocytosed and removed from the body, and small enough in diameter to not physically inhibit bone growth at said bony defect site. The microspheres are formed of polylactic-co-glycolic acid (PLGA), with or without polyethylene glycol (PEG), and sufficient antibiotic agent to produce bactericidal levels in body tissues. The microspheres exhibit near-linear delivery of the antibiotic agent for at least 4 weeks at levels exceeding the minimum inhibitory concentration (MIC) for organisms commonly found to be the cause of infections, and facilitate bone ingrowth or regrowth at the site.eng
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposeseng
dc.format.extent17 ppeng
dc.identifier.citationAmbrose, Catherine G., Clyburn, Terry A. and Mikos, Antonio G., "Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth." Patent US8986737B2. issued 2015-03-24. Retrieved from <a href="https://hdl.handle.net/1911/87472">https://hdl.handle.net/1911/87472</a>.*
dc.identifier.patentIDUS8986737B2eng
dc.identifier.urihttps://hdl.handle.net/1911/87472
dc.language.isoengeng
dc.titleAntibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowtheng
dc.typeUtility patenteng
dc.type.dcmiTexteng
dc.type.genrepatentseng
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