Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering

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dc.citation.articleNumbereaaw7396en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleScience Advancesen_US
dc.citation.volumeNumber5en_US
dc.contributor.authorGuo, J.L.en_US
dc.contributor.authorKim, Y.S.en_US
dc.contributor.authorXie, V.Y.en_US
dc.contributor.authorSmith, B.T.en_US
dc.contributor.authorWatson, E.en_US
dc.contributor.authorLam, J.en_US
dc.contributor.authorPearce, H.A.en_US
dc.contributor.authorEngel, P.S.en_US
dc.contributor.authorMikos, A.G.en_US
dc.date.accessioned2019-09-17T17:11:46Zen_US
dc.date.available2019-09-17T17:11:46Zen_US
dc.date.issued2019en_US
dc.description.abstractSynthetic hydrogels are investigated extensively in tissue engineering for their tunable physicochemical properties but are bioinert and lack the tissue-specific cues to produce appropriate biological responses. To introduce tissue-specific biochemical cues to these hydrogels, we have developed a modular hydrogel cross-linker, poly(glycolic acid)-poly(ethylene glycol)-poly(glycolic acid)-di(but-2-yne-1,4-dithiol) (PdBT), that can be functionalized with small peptide-based cues and large macromolecular cues simply by mixing PdBT in water with the appropriate biomolecules at room temperature. Cartilage- and bone-specific PdBT macromers were generated by functionalization with a cartilage-associated hydrophobic N-cadherin peptide, a hydrophilic bone morphogenetic protein peptide, and a cartilage-derived glycosaminoglycan, chondroitin sulfate. These biofunctionalized PdBT macromers can spontaneously cross-link polymers such as poly(N-isopropylacrylamide) to produce rapidly cross-linking, highly swollen, cytocompatible, and hydrolytically degradable hydrogels suitable for mesenchymal stem cell encapsulation. These favorable properties, combined with PdBT's modular design and ease of functionalization, establish strong potential for its usage in tissue engineering applications.en_US
dc.identifier.citationGuo, J.L., Kim, Y.S., Xie, V.Y., et al.. "Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering." <i>Science Advances,</i> 5, no. 6 (2019) AAAS: https://doi.org/10.1126/sciadv.aaw7396.en_US
dc.identifier.digitaleaaw7396en_US
dc.identifier.doihttps://doi.org/10.1126/sciadv.aaw7396en_US
dc.identifier.urihttps://hdl.handle.net/1911/107414en_US
dc.language.isoengen_US
dc.publisherAAASen_US
dc.rightsDistributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.titleModular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineeringen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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