Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering

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dc.citation.articleNumbereaaw7396
dc.citation.issueNumber6
dc.citation.journalTitleScience Advances
dc.citation.volumeNumber5
dc.contributor.authorGuo, J.L.
dc.contributor.authorKim, Y.S.
dc.contributor.authorXie, V.Y.
dc.contributor.authorSmith, B.T.
dc.contributor.authorWatson, E.
dc.contributor.authorLam, J.
dc.contributor.authorPearce, H.A.
dc.contributor.authorEngel, P.S.
dc.contributor.authorMikos, A.G.
dc.date.accessioned2019-09-17T17:11:46Z
dc.date.available2019-09-17T17:11:46Z
dc.date.issued2019
dc.description.abstractSynthetic hydrogels are investigated extensively in tissue engineering for their tunable physicochemical properties but are bioinert and lack the tissue-specific cues to produce appropriate biological responses. To introduce tissue-specific biochemical cues to these hydrogels, we have developed a modular hydrogel cross-linker, poly(glycolic acid)-poly(ethylene glycol)-poly(glycolic acid)-di(but-2-yne-1,4-dithiol) (PdBT), that can be functionalized with small peptide-based cues and large macromolecular cues simply by mixing PdBT in water with the appropriate biomolecules at room temperature. Cartilage- and bone-specific PdBT macromers were generated by functionalization with a cartilage-associated hydrophobic N-cadherin peptide, a hydrophilic bone morphogenetic protein peptide, and a cartilage-derived glycosaminoglycan, chondroitin sulfate. These biofunctionalized PdBT macromers can spontaneously cross-link polymers such as poly(N-isopropylacrylamide) to produce rapidly cross-linking, highly swollen, cytocompatible, and hydrolytically degradable hydrogels suitable for mesenchymal stem cell encapsulation. These favorable properties, combined with PdBT's modular design and ease of functionalization, establish strong potential for its usage in tissue engineering applications.
dc.identifier.citationGuo, J.L., Kim, Y.S., Xie, V.Y., et al.. "Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering." <i>Science Advances,</i> 5, no. 6 (2019) AAAS: https://doi.org/10.1126/sciadv.aaw7396.
dc.identifier.digitaleaaw7396
dc.identifier.doihttps://doi.org/10.1126/sciadv.aaw7396
dc.identifier.urihttps://hdl.handle.net/1911/107414
dc.language.isoeng
dc.publisherAAAS
dc.rightsDistributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleModular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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