Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018

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dc.contributor.authorMeisel, Jacquelyn S.
dc.contributor.authorNasko, Daniel J.
dc.contributor.authorBrubach, Brian
dc.contributor.authorCepeda-Espinoza, Victoria
dc.contributor.authorChopyk, Jessica
dc.contributor.authorCorrada-Bravo, Héctor
dc.contributor.authorFedarko, Marcus
dc.contributor.authorGhurye, Jay
dc.contributor.authorJavkar, Kiran
dc.contributor.authorOlson, Nathan D.
dc.contributor.authorShah, Nidhi
dc.contributor.authorAllard, Sarah M.
dc.contributor.authorBazinet, Adam L.
dc.contributor.authorBergman, Nicholas H.
dc.contributor.authorBrown, Alexis
dc.contributor.authorCaporaso, J.G.
dc.contributor.authorConlan, Sean
dc.contributor.authorDiRuggiero, Jocelyne
dc.contributor.authorForry, Samuel P.
dc.contributor.authorHasan, Nur A.
dc.contributor.authorKralj, Jason
dc.contributor.authorLuethy, Paul M.
dc.contributor.authorMilton, Donald K.
dc.contributor.authorOndov, Brian D.
dc.contributor.authorPreheim, Sarah
dc.contributor.authorRatnayake, Shashikala
dc.contributor.authorRogers, Stephanie M.
dc.contributor.authorRosovitz, M.J.
dc.contributor.authorSakowski, Eric G.
dc.contributor.authorSchliebs, Nils O.
dc.contributor.authorSommer, Daniel D.
dc.contributor.authorTernus, Krista L.
dc.contributor.authorUritskiy, Gherman
dc.contributor.authorZhang, Sean X.
dc.contributor.authorPop, Mihai
dc.contributor.authorTreangen, Todd J.
dc.date.accessioned2018-11-28T16:44:07Z
dc.date.available2018-11-28T16:44:07Z
dc.date.issued2018-11-05
dc.date.updated2018-11-28T16:44:07Z
dc.description.abstractAbstract The Mid-Atlantic Microbiome Meet-up (M3) organization brings together academic, government, and industry groups to share ideas and develop best practices for microbiome research. In January of 2018, M3 held its fourth meeting, which focused on recent advances in biodefense, specifically those relating to infectious disease, and the use of metagenomic methods for pathogen detection. Presentations highlighted the utility of next-generation sequencing technologies for identifying and tracking microbial community members across space and time. However, they also stressed the current limitations of genomic approaches for biodefense, including insufficient sensitivity to detect low-abundance pathogens and the inability to quantify viable organisms. Participants discussed ways in which the community can improve software usability and shared new computational tools for metagenomic processing, assembly, annotation, and visualization. Looking to the future, they identified the need for better bioinformatics toolkits for longitudinal analyses, improved sample processing approaches for characterizing viruses and fungi, and more consistent maintenance of database resources. Finally, they addressed the necessity of improving data standards to incentivize data sharing. Here, we summarize the presentations and discussions from the meeting, identifying the areas where microbiome analyses have improved our ability to detect and manage biological threats and infectious disease, as well as gaps of knowledge in the field that require future funding and focus.
dc.identifier.citationMeisel, Jacquelyn S., Nasko, Daniel J., Brubach, Brian, et al.. "Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018." (2018) BioMed Central: https://doi.org/10.1186/s40168-018-0582-5.
dc.identifier.doihttps://doi.org/10.1186/s40168-018-0582-5
dc.identifier.urihttps://hdl.handle.net/1911/103432
dc.language.rfc3066en
dc.publisherBioMed Central
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.holderThe Author(s).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleCurrent progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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