Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies

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dc.citation.firstpage4639en_US
dc.citation.issueNumber11en_US
dc.citation.journalTitleBiomedical Optics Expressen_US
dc.citation.lastpage4653en_US
dc.citation.volumeNumber7en_US
dc.contributor.authorSubramanian, Kaushiken_US
dc.contributor.authorGabay, Ilanen_US
dc.contributor.authorFerhanoğlu, Onuren_US
dc.contributor.authorShadfan, Adamen_US
dc.contributor.authorPawlowski, Michalen_US
dc.contributor.authorWang, Yeen_US
dc.contributor.authorTkaczyk, Tomaszen_US
dc.contributor.authorBen-Yakar, Adelaen_US
dc.date.accessioned2016-12-01T17:29:09Zen_US
dc.date.available2016-12-01T17:29:09Zen_US
dc.date.issued2016en_US
dc.description.abstractWe present the development of a 5 mm, piezo-actuated, ultrafast laser scalpel for fast tissue microsurgery. Delivery of micro-Joules level energies to the tissue was made possible by a large, 31 μm, air-cored inhibited-coupling Kagome fiber. We overcome the fiber’s low NA by using lenses made of high refractive index ZnS, which produced an optimal focusing condition with 0.23 NA objective. The optical design achieved a focused laser spot size of 4.5 μm diameter covering a 75 × 75 μm2 scan area in a miniaturized setting. The probe could deliver the maximum available laser power, achieving an average fluence of 7.8 J/cm2 on the tissue surface at 62% transmission efficiency. Such fluences could produce uninterrupted, 40 μm deep cuts at translational speeds of up to 5 mm/s along the tissue. We predicted that the best combination of speed and coverage exists at 8 mm/s for our conditions. The onset of nonlinear absorption in ZnS, however, limited the probe’s energy delivery capabilities to 1.4 μJ for linear operation at 1.5 picosecond pulse-widths of our fiber laser. Alternatives like broadband CaF2 crystals should mitigate such nonlinear limiting behavior. Improved opto-mechanical design and appropriate material selection should allow substantially higher fluence delivery and propel such Kagome fiber-based scalpels towards clinical translation.en_US
dc.identifier.citationSubramanian, Kaushik, Gabay, Ilan, Ferhanoğlu, Onur, et al.. "Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies." <i>Biomedical Optics Express,</i> 7, no. 11 (2016) The Optical Society: 4639-4653. http://dx.doi.org/10.1364/BOE.7.004639.en_US
dc.identifier.doihttp://dx.doi.org/10.1364/BOE.7.004639en_US
dc.identifier.urihttps://hdl.handle.net/1911/92733en_US
dc.language.isoengen_US
dc.publisherThe Optical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleKagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energiesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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