Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies

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dc.citation.firstpage4639
dc.citation.issueNumber11
dc.citation.journalTitleBiomedical Optics Express
dc.citation.lastpage4653
dc.citation.volumeNumber7
dc.contributor.authorSubramanian, Kaushik
dc.contributor.authorGabay, Ilan
dc.contributor.authorFerhanoğlu, Onur
dc.contributor.authorShadfan, Adam
dc.contributor.authorPawlowski, Michal
dc.contributor.authorWang, Ye
dc.contributor.authorTkaczyk, Tomasz
dc.contributor.authorBen-Yakar, Adela
dc.date.accessioned2016-12-01T17:29:09Z
dc.date.available2016-12-01T17:29:09Z
dc.date.issued2016
dc.description.abstractWe present the development of a 5 mm, piezo-actuated, ultrafast laser scalpel for fast tissue microsurgery. Delivery of micro-Joules level energies to the tissue was made possible by a large, 31 μm, air-cored inhibited-coupling Kagome fiber. We overcome the fiber’s low NA by using lenses made of high refractive index ZnS, which produced an optimal focusing condition with 0.23 NA objective. The optical design achieved a focused laser spot size of 4.5 μm diameter covering a 75 × 75 μm2 scan area in a miniaturized setting. The probe could deliver the maximum available laser power, achieving an average fluence of 7.8 J/cm2 on the tissue surface at 62% transmission efficiency. Such fluences could produce uninterrupted, 40 μm deep cuts at translational speeds of up to 5 mm/s along the tissue. We predicted that the best combination of speed and coverage exists at 8 mm/s for our conditions. The onset of nonlinear absorption in ZnS, however, limited the probe’s energy delivery capabilities to 1.4 μJ for linear operation at 1.5 picosecond pulse-widths of our fiber laser. Alternatives like broadband CaF2 crystals should mitigate such nonlinear limiting behavior. Improved opto-mechanical design and appropriate material selection should allow substantially higher fluence delivery and propel such Kagome fiber-based scalpels towards clinical translation.
dc.identifier.citationSubramanian, Kaushik, Gabay, Ilan, Ferhanoğlu, Onur, et al.. "Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies." <i>Biomedical Optics Express,</i> 7, no. 11 (2016) The Optical Society: 4639-4653. http://dx.doi.org/10.1364/BOE.7.004639.
dc.identifier.doihttp://dx.doi.org/10.1364/BOE.7.004639
dc.identifier.urihttps://hdl.handle.net/1911/92733
dc.language.isoeng
dc.publisherThe Optical Society
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titleKagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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