Measurement of mechanical tractions exerted by cells within three-dimensional matrices

Simple item page
dc.citation.firstpage969en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitleNature Methodsen_US
dc.citation.lastpage971en_US
dc.citation.volumeNumber7en_US
dc.contributor.authorLegant, Wesley R.en_US
dc.contributor.authorMiller, Jordan S.en_US
dc.contributor.authorBlakely, Brandon L.en_US
dc.contributor.authorCohen, Daniel M.en_US
dc.contributor.authorGenin, Guy M.en_US
dc.contributor.authorChen, Christopher S.en_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2014-09-22T20:23:28Zen_US
dc.date.available2014-09-22T20:23:28Zen_US
dc.date.issued2010en_US
dc.description.abstractQuantitative measurements of cell-generated forces have heretofore required that cells be cultured on two-dimensional substrates. We describe a technique to quantitatively measure three-dimensional traction forces exerted by cells fully encapsulated within well-defined elastic hydrogel matrices. We apply this approach to measure tractions from a variety of cell types and contexts, and reveal patterns of force generation attributable to morphologically distinct regions of cells as they extend into the surrounding matrix.en_US
dc.identifier.citationLegant, Wesley R., Miller, Jordan S., Blakely, Brandon L., et al.. "Measurement of mechanical tractions exerted by cells within three-dimensional matrices." <i>Nature Methods,</i> 7, no. 12 (2010) Nature Publishing Group: 969-971. http://dx.doi.org/10.1038/nmeth.1531.en_US
dc.identifier.doihttp://dx.doi.org/10.1038/nmeth.1531en_US
dc.identifier.urihttps://hdl.handle.net/1911/77219en_US
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Nature Publishing Group.en_US
dc.titleMeasurement of mechanical tractions exerted by cells within three-dimensional matricesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nihms278282.pdf
Size:
241.22 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications