Measurement of mechanical tractions exerted by cells within three-dimensional matrices

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dc.citation.firstpage969
dc.citation.issueNumber12
dc.citation.journalTitleNature Methods
dc.citation.lastpage971
dc.citation.volumeNumber7
dc.contributor.authorLegant, Wesley R.
dc.contributor.authorMiller, Jordan S.
dc.contributor.authorBlakely, Brandon L.
dc.contributor.authorCohen, Daniel M.
dc.contributor.authorGenin, Guy M.
dc.contributor.authorChen, Christopher S.
dc.date.accessioned2014-09-22T20:23:28Z
dc.date.available2014-09-22T20:23:28Z
dc.date.issued2010
dc.description.abstractQuantitative measurements of cell-generated forces have heretofore required that cells be cultured on two-dimensional substrates. We describe a technique to quantitatively measure three-dimensional traction forces exerted by cells fully encapsulated within well-defined elastic hydrogel matrices. We apply this approach to measure tractions from a variety of cell types and contexts, and reveal patterns of force generation attributable to morphologically distinct regions of cells as they extend into the surrounding matrix.
dc.identifier.citationLegant, Wesley R., Miller, Jordan S., Blakely, Brandon L., et al.. "Measurement of mechanical tractions exerted by cells within three-dimensional matrices." <i>Nature Methods,</i> 7, no. 12 (2010) Nature Publishing Group: 969-971. http://dx.doi.org/10.1038/nmeth.1531.
dc.identifier.doihttp://dx.doi.org/10.1038/nmeth.1531
dc.identifier.urihttps://hdl.handle.net/1911/77219
dc.language.isoeng
dc.publisherNature Publishing Group
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Nature Publishing Group.
dc.titleMeasurement of mechanical tractions exerted by cells within three-dimensional matrices
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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