Miniature, minimally invasive, tunable endoscope for investigation of the middle ear

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dc.citation.firstpage2246en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleBiomedical Optics Expressen_US
dc.citation.lastpage2257en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorPawlowski, Michal E.en_US
dc.contributor.authorShrestha, Sebinaen_US
dc.contributor.authorPark, Jesungen_US
dc.contributor.authorApplegate, Brian E.en_US
dc.contributor.authorOghalai, John S.en_US
dc.contributor.authorTkaczyk, Tomasz S.en_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2015-06-30T16:22:57Zen_US
dc.date.available2015-06-30T16:22:57Zen_US
dc.date.issued2015en_US
dc.description.abstractWe demonstrate a miniature, tunable, minimally invasive endoscope for diagnosis of the auditory system. The probe is designed to sharply image anatomical details of the middle ear without the need for physically adjusting the position of the distal end of the endoscope. This is achieved through the addition of an electrowetted, tunable, electronically-controlled lens to the optical train. Morphological imaging is enabled by scanning light emanating from an optical coherence tomography system. System performance was demonstrated by imaging part of the ossicular chain and wall of the middle ear cavity of a normal mouse. During the experiment, we electronically moved the plane of best focus from the incudo-stapedial joint to the stapedial artery. Repositioning the object plane allowed us to image anatomical details of the middle ear beyond the depth of field of a static optical system. We also demonstrated for the first time to our best knowledge, that an optical system with an electrowetted, tunable lens may be successfully employed to measure sound-induced vibrations within the auditory system by measuring the vibratory amplitude of the tympanic membrane in a normal mouse in response to pure tone stimuli.en_US
dc.identifier.citationPawlowski, Michal E., Shrestha, Sebina, Park, Jesung, et al.. "Miniature, minimally invasive, tunable endoscope for investigation of the middle ear." <i>Biomedical Optics Express,</i> 6, no. 6 (2015) The Optical Society: 2246-2257. http://dx.doi.org/10.1364/BOE.6.002246.en_US
dc.identifier.doihttp://dx.doi.org/10.1364/BOE.6.002246en_US
dc.identifier.urihttps://hdl.handle.net/1911/80840en_US
dc.language.isoengen_US
dc.publisherThe Optical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleMiniature, minimally invasive, tunable endoscope for investigation of the middle earen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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