Design of a Fast, Efficient and Controlled DNA Shearing System Based on Lateral Acoustic Waves

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dc.contributor.advisorMassoud, Yehiaen_US
dc.creatorDev, Kapilen_US
dc.date.accessioned2013-03-08T00:33:20Zen_US
dc.date.available2013-03-08T00:33:20Zen_US
dc.date.issued2012en_US
dc.description.abstractWith the continuous research and advances in Deoxyribonucleic acid (DNA) sequencing technologies, the need for an efficient DNA shearing system has increased more than ever before. In this thesis, we propose a fast, efficient and controlled DNA shearing system based on a uniquely designed ultrasonic transducer, called Fresnel Annular Sector Actuator (FASA). Based on the simulation and experimental results, a circular array of four 90°-FASA elements is chosen as the basic unit for the proposed shearing system. DNA is successfully sheared from 300 to 1500 base-pair lengths. The shearing performance of the system is independent of the source of DNA over a large range of concentrations of the DNA. Finally, multiple FASA elements, excited by separate BF-signals, are used to increase the throughput of the proposed shearing system.en_US
dc.format.extent96 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS E.E. 2012 DEVen_US
dc.identifier.citationDev, Kapil. "Design of a Fast, Efficient and Controlled DNA Shearing System Based on Lateral Acoustic Waves." (2012) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/70227">https://hdl.handle.net/1911/70227</a>.en_US
dc.identifier.digitalDevKen_US
dc.identifier.urihttps://hdl.handle.net/1911/70227en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectApplied sciencesen_US
dc.subjectBiomedical engineeringen_US
dc.subjectElectrical engineeringen_US
dc.titleDesign of a Fast, Efficient and Controlled DNA Shearing System Based on Lateral Acoustic Wavesen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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