Au Nanomatryoshkas as Efficient Near-Infrared Photothermal Transducers for Cancer Treatment: Benchmarking against Nanoshells

Simple item page
dc.citation.firstpage6372en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleACS Nanoen_US
dc.citation.lastpage6381en_US
dc.citation.volumeNumber8en_US
dc.contributor.authorAyala-Orozco, Ciceronen_US
dc.contributor.authorUrban, Cordulaen_US
dc.contributor.authorKnight, Mark W.en_US
dc.contributor.authorUrban, Alexander Skyrmeen_US
dc.contributor.authorNeumann, Oaraen_US
dc.contributor.authorBishnoi, Sandra W.en_US
dc.contributor.authorMukherjee, Shaunaken_US
dc.contributor.authorGoodman, Amanda M.en_US
dc.contributor.authorCharron, Heatheren_US
dc.contributor.authorMitchell, Tamikaen_US
dc.contributor.authorShea, Martinen_US
dc.contributor.authorRoy, Ronitaen_US
dc.contributor.authorNanda, Sarmisthaen_US
dc.contributor.authorSchiff, Rachelen_US
dc.contributor.authorHalas, Naomi J.en_US
dc.contributor.authorJoshi, Amiten_US
dc.date.accessioned2015-07-10T15:47:02Zen_US
dc.date.available2015-07-10T15:47:02Zen_US
dc.date.issued2014en_US
dc.description.abstractAu nanoparticles with plasmon resonances in the near-infrared (NIR) region of the spectrum efficiently convert light into heat, a property useful for the photothermal ablation of cancerous tumors subsequent to nanoparticle uptake at the tumor site. A critical aspect of this process is nanoparticle size, which influences both tumor uptake and photothermal efficiency. Here, we report a direct comparative study of ∼90 nm diameter Au nanomatryoshkas (Au/SiO2/Au) and ∼150 nm diameter Au nanoshells for photothermal therapeutic efficacy in highly aggressive triple negative breast cancer (TNBC) tumors in mice. Au nanomatryoshkas are strong light absorbers with 77% absorption efficiency, while the nanoshells are weaker absorbers with only 15% absorption efficiency. After an intravenous injection of Au nanomatryoshkas followed by a single NIR laser dose of 2 W/cm2 for 5 min, 83% of the TNBC tumor-bearing mice appeared healthy and tumor free >60 days later, while only 33% of mice treated with nanoshells survived the same period. The smaller size and larger absorption cross section of Au nanomatryoshkas combine to make this nanoparticle more effective than Au nanoshells for photothermal cancer therapy.en_US
dc.identifier.citationAyala-Orozco, Ciceron, Urban, Cordula, Knight, Mark W., et al.. "Au Nanomatryoshkas as Efficient Near-Infrared Photothermal Transducers for Cancer Treatment: Benchmarking against Nanoshells." <i>ACS Nano,</i> 8, no. 6 (2014) American Chemical Society: 6372-6381. http://dx.doi.org/10.1021/nn501871d.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/nn501871den_US
dc.identifier.urihttps://hdl.handle.net/1911/80886en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordnanomatryoshkaen_US
dc.subject.keywordmultilayer nanoshells Au/SiO2/Auen_US
dc.subject.keywordphotothermal therapyen_US
dc.subject.keywordnear-infrareden_US
dc.subject.keywordAu nanoparticleen_US
dc.titleAu Nanomatryoshkas as Efficient Near-Infrared Photothermal Transducers for Cancer Treatment: Benchmarking against Nanoshellsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nn501871d.pdf
Size:
3.86 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Chemistry Publications
ECE Publications