The Surprising in Vivo Instability of Near-IR-Absorbing Hollow Au-Ag Nanoshells

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dc.citation.firstpage3222
dc.citation.issueNumber4
dc.citation.journalTitleACS Nano
dc.citation.lastpage3231
dc.citation.volumeNumber8
dc.contributor.authorGoodman, Amanda M.
dc.contributor.authorCao, Yang
dc.contributor.authorUrban, Cordula
dc.contributor.authorNeumann, Oara
dc.contributor.authorAyala-Orozco, Ciceron
dc.contributor.authorKnight, Mark W.
dc.contributor.authorJoshi, Amit
dc.contributor.authorNordlander, Peter
dc.contributor.authorHalas, Naomi J.
dc.date.accessioned2015-03-19T15:07:12Z
dc.date.available2015-03-19T15:07:12Z
dc.date.issued2014
dc.description.abstractPhotothermal ablation based on resonant illumination of near-infrared-absorbing noble metal nanoparticles that have accumulated in tumors is a highly promising cancer therapy, currently in multiple clinical trials. A crucial aspect of this therapy is the nanoparticle size for optimal tumor uptake. A class of nanoparticles known as hollow Au (or Au–Ag) nanoshells (HGNS) is appealing because near-IR resonances are achievable in this system with diameters less than 100 nm. However, in this study, we report a surprising finding that in vivo HGNS are unstable, fragmenting with the Au and the remnants of the sacrificial Ag core accumulating differently in various organs. We synthesized 43, 62, and 82 nm diameter HGNS through a galvanic replacement reaction, with nanoparticles of all sizes showing virtually identical NIR resonances at ∼800 nm. A theoretical model indicated that alloying, residual Ag in the nanoparticle core, nanoparticle porosity, and surface defects all contribute to the presence of the plasmon resonance at the observed wavelength, with the major contributing factor being the residual Ag. While PEG functionalization resulted in stable nanoparticles under laser irradiation in solution, an anomalous, strongly element-specific biodistribution observed in tumor-bearing mice suggests that an avid fragmentation of all three sizes of nanoparticles occurred in vivo. Stability studies across a wide range of pH environments and in serum confirmed HGNS fragmentation. These results show that NIR resonant HGNS contain residual Ag, which does not stay contained within the HGNS in vivo. This demonstrates the importance of tracking both materials of a galvanic replacement nanoparticle in biodistribution studies and of performing thorough nanoparticle stability studies prior to any intended in vivo trial application.
dc.identifier.citationGoodman, Amanda M., Cao, Yang, Urban, Cordula, et al.. "The Surprising in Vivo Instability of Near-IR-Absorbing Hollow Au-Ag Nanoshells." <i>ACS Nano,</i> 8, no. 4 (2014) American Chemical Society: 3222-3231. http://dx.doi.org/10.1021/nn405663h.
dc.identifier.doihttp://dx.doi.org/10.1021/nn405663h
dc.identifier.urihttps://hdl.handle.net/1911/79390
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.subject.keywordplasmon
dc.subject.keywordfragmentation
dc.subject.keywordserum
dc.subject.keywordnear-infrared
dc.subject.keywordphotothermal therapy
dc.subject.keywordnanomedicine
dc.subject.keywordcancer
dc.titleThe Surprising in Vivo Instability of Near-IR-Absorbing Hollow Au-Ag Nanoshells
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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