New synthetic reactions: Applications to discorhabdins and carbacephems

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dc.contributor.advisorCiufolini, Marco A.en_US
dc.creatorDong, Qingen_US
dc.date.accessioned2009-06-04T00:40:56Zen_US
dc.date.available2009-06-04T00:40:56Zen_US
dc.date.issued1996en_US
dc.description.abstractA novel approach for the synthesis of antitumor agents Discorhabdins (1) is described. The synthetic route features a new Paterno-Buchi photo reaction for the spirocyclic ring preparation and cascade Michael reactions for the construction of pyrrolidine unit. The preparation of an advanced intermediate (2) will be discussed.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI) A parallel investigation deals with the application of an Aza-Achmatowicz rearrangement for the synthesis of carbacephems. Both cis and trans series of bicyclic $\beta$-lactams were easily available through the Aza-Achmatowicz sequence.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)en_US
dc.format.extent241 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS CHEM. 1996 DONGen_US
dc.identifier.citationDong, Qing. "New synthetic reactions: Applications to discorhabdins and carbacephems." (1996) Diss., Rice University. <a href="https://hdl.handle.net/1911/16923">https://hdl.handle.net/1911/16923</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/16923en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectOrganic chemistryen_US
dc.subjectPharmaceutical chemistryen_US
dc.titleNew synthetic reactions: Applications to discorhabdins and carbacephemsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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