New synthetic reactions: Applications to discorhabdins and carbacephems

Files
9631071.PDF (5.06 MB)
Date
1996
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract

A novel approach for the synthesis of antitumor agents Discorhabdins (1) is described. The synthetic route features a new Paterno-Buchi photo reaction for the spirocyclic ring preparation and cascade Michael reactions for the construction of pyrrolidine unit. The preparation of an advanced intermediate (2) will be discussed.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI) A parallel investigation deals with the application of an Aza-Achmatowicz rearrangement for the synthesis of carbacephems. Both cis and trans series of bicyclic β-lactams were easily available through the Aza-Achmatowicz sequence.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)

Description
Advisor
Ciufolini, Marco A.
Degree
Doctor of Philosophy
Type
Thesis
Keywords
Organic chemistry, Pharmaceutical chemistry
Citation

Dong, Qing. "New synthetic reactions: Applications to discorhabdins and carbacephems." (1996) Diss., Rice University. https://hdl.handle.net/1911/16923.

Has part(s)
Forms part of
Published Version
Rights
Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
Link to license
Citable link to this page
https://hdl.handle.net/1911/16923
Collections
Rice University Theses and Dissertations