Biomechanical forces in tissue engineered tumor models

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dc.citation.firstpage42
dc.citation.journalTitleCurrent Opinion in Biomedical Engineering
dc.citation.lastpage50
dc.citation.volumeNumber6
dc.contributor.authorChim, Letitia K.
dc.contributor.authorMikos, Antonios G.
dc.date.accessioned2019-11-22T16:19:58Z
dc.date.available2019-11-22T16:19:58Z
dc.date.issued2018
dc.description.abstractSolid tumors are complex three-dimensional (3D) networks of cancer and stromal cells within a dynamic extracellular matrix. Monolayer cultures fail to recapitulate the native microenvironment and therefore are poor candidates for pre-clinical drug studies and studying pathways in cancer. The tissue engineering toolkit allows us to make models that better recapitulate the 3D architecture present in tumors. Moreover, the role of the mechanical microenvironment, including matrix stiffness and shear stress from fluid flow, is known to contribute to cancer progression and drug resistance. We review recent developments in tissue engineered tumor models with a focus on the role of the biomechanical forces and propose future considerations to implement to improve physiological relevance of such models.
dc.identifier.citationChim, Letitia K. and Mikos, Antonios G.. "Biomechanical forces in tissue engineered tumor models." <i>Current Opinion in Biomedical Engineering,</i> 6, (2018) Elsevier: 42-50. https://doi.org/10.1016/j.cobme.2018.03.004.
dc.identifier.digitalnihms954447
dc.identifier.doihttps://doi.org/10.1016/j.cobme.2018.03.004
dc.identifier.urihttps://hdl.handle.net/1911/107724
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier
dc.subject.keywordex vivo tumor model
dc.subject.keywordMatrix stiffness
dc.subject.keywordShear stress
dc.subject.keywordTissue engineering
dc.titleBiomechanical forces in tissue engineered tumor models
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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