Competitive compositions of nucleic acid molecules for enrichment of rare-allele-bearing species

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dc.contributor.assigneeRice University
dc.contributor.publisherUnited States Patent and Trademark Office
dc.creatorZhang, David Yu
dc.creatorWang, Juexiao
dc.date.accessioned2022-02-28T20:08:21Z
dc.date.available2022-02-28T20:08:21Z
dc.date.filed2016-10-17
dc.date.issued2021-08-31
dc.description.abstractThe present disclosure describes the thermodynamic design and concentrations necessary to design probe compositions with desired optimal specificity that enable enrichment, detection, quantitation, purification, imaging, and amplification of rare-allele-bearing species of nucleic acids (prevalence <1%) in a large stoichiometric excess of a dominant-allele-bearing species (wildtype). Being an enzyme-free and homogeneous nucleic acid enrichment composition, this technology is broadly compatible with nearly all nucleic acid-based biotechnology, including plate reader and fluorimeter readout of nucleic acids, microarrays, PCR and other enzymatic amplification reactions, fluorescence barcoding, nanoparticle-based purification and quantitation, and in situ hybridization imaging technologies.
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.
dc.format.extent85
dc.identifier.citationZhang, David Yu and Wang, Juexiao, "Competitive compositions of nucleic acid molecules for enrichment of rare-allele-bearing species." Patent US11104936B2. issued 2021-08-31. Retrieved from <a href="https://hdl.handle.net/1911/111995">https://hdl.handle.net/1911/111995</a>.
dc.identifier.patentIDUS11104936B2
dc.identifier.urihttps://hdl.handle.net/1911/111995
dc.language.isoeng
dc.language.isoEnglish
dc.titleCompetitive compositions of nucleic acid molecules for enrichment of rare-allele-bearing species
dc.typeUtility patent
dc.type.dcmiText
dc.type.genrepatents
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