Metal nanoshells for biosensing applications

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dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorWest, Jennifer L.en_US
dc.creatorHalas, Nancy J.en_US
dc.creatorOldenburg, Steven J.en_US
dc.creatorAveritt, Richard D.en_US
dc.date.accessioned2015-05-04T19:05:33Z
dc.date.available2015-05-04T19:05:33Z
dc.date.filed2000-07-14en_US
dc.date.issued2004-03-02en_US
dc.description.abstractThe present invention provides nanoshell particles (“nanoshells”) for use in biosensing applications, along with their manner of making and methods of using the nanoshells for in vitro and in vivo detection of chemical and biological analytes, preferably by surface enhanced Raman light scattering. The preferred particles have a non-conducting core and a metal shell surrounding the core. For given core and shell materials, the ratio of the thickness (i.e., radius) of the core to the thickness of the metal shell is determinative of the wavelength of maximum absorbance of the particle. By controlling the relative core and shell thicknesses, biosensing metal nanoshells are fabricated which absorb light at any desired wavelength across the ultraviolet to infrared range of the electromagnetic spectrum. The surface of the particles are capable of inducing an enhanced SERS signal that is characteristic of an analyte of interest. In certain embodiments a biomolecule is conjugated to the metal shell and the SERS signal of a conformational change or a reaction product is detected.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.en_US
dc.format.extent20 ppen_US
dc.identifier.citationWest, Jennifer L., Halas, Nancy J., Oldenburg, Steven J. and Averitt, Richard D., "Metal nanoshells for biosensing applications." Patent US6699724B1. issued 2004-03-02. Retrieved from https://hdl.handle.net/1911/79864.
dc.identifier.patentIDUS6699724B1en_US
dc.identifier.urihttps://hdl.handle.net/1911/79864
dc.language.isoengen_US
dc.titleMetal nanoshells for biosensing applicationsen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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