Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines

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dc.citation.firstpage18937en_US
dc.citation.issueNumber38en_US
dc.citation.journalTitleProceedings of the National Academy of Sciencesen_US
dc.citation.lastpage18942en_US
dc.citation.volumeNumber116en_US
dc.contributor.authorWang, Qianen_US
dc.contributor.authorChen, Mingchenen_US
dc.contributor.authorSchafer, Nicholas P.en_US
dc.contributor.authorBueno, Carlosen_US
dc.contributor.authorSong, Sarah S.en_US
dc.contributor.authorHudmon, Andyen_US
dc.contributor.authorWolynes, Peter G.en_US
dc.contributor.authorWaxham, M. Nealen_US
dc.contributor.authorCheung, Margaret S.en_US
dc.date.accessioned2019-10-25T16:54:17Zen_US
dc.date.available2019-10-25T16:54:17Zen_US
dc.date.issued2019en_US
dc.description.abstractThe structural dynamics of the dendritic synapse, arising from the remodeling of actin cytoskeletons, has been widely associated with memory and cognition. The remodeling is regulated by intracellular Ca2+ levels. Under low Ca2+ concentration, actin filaments are bundled by a calcium signaling protein, CaMKII. When the Ca2+ concentration is raised, CaMKII dissociates from actin and opens the window for actin remodeling. At present, the molecular details of the actin bundling and regulation are elusive. Herein we use experimental tools along with molecular simulations to construct a model of how CaMKII bundles actin and how the CaMKII–actin architecture is regulated by Ca2+ signals. In this way, our results explain how Ca2+ signals ultimately change the structure of the dendritic synapse.en_US
dc.identifier.citationWang, Qian, Chen, Mingchen, Schafer, Nicholas P., et al.. "Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines." <i>Proceedings of the National Academy of Sciences,</i> 116, no. 38 (2019) National Academy of Sciences: 18937-18942. https://doi.org/10.1073/pnas.1911452116.en_US
dc.identifier.doihttps://doi.org/10.1073/pnas.1911452116en_US
dc.identifier.urihttps://hdl.handle.net/1911/107503en_US
dc.language.isoengen_US
dc.publisherNational Academy of Sciencesen_US
dc.rightsThis open access article is distributed underﾠCreative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleAssemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spinesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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