OVOL guides the epithelial-hybrid-mesenchymal transition

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dc.citation.firstpage15436
dc.citation.issueNumber17
dc.citation.journalTitleOncotarget
dc.citation.lastpage15448
dc.citation.volumeNumber6
dc.contributor.authorJia, Dongya
dc.contributor.authorJolly, Mohit Kumar
dc.contributor.authorBoareto, Marcelo
dc.contributor.authorParsana, Princy
dc.contributor.authorMooney, Steven M.
dc.contributor.authorPienta, Kenneth J.
dc.contributor.authorLevine, Herbert
dc.contributor.authorBen-Jacob, Eshel
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2016-06-22T16:28:31Z
dc.date.available2016-06-22T16:28:31Z
dc.date.issued2015
dc.description.abstractMetastasis involves multiple cycles of Epithelial-to-Mesenchymal Transition (EMT) and its reverse-MET. Cells can also undergo partial transitions to attain a hybrid epithelial/mesenchymal (E/M) phenotype that has maximum cellular plasticity and allows migration of Circulating Tumor Cells (CTCs) as a cluster. Hence, deciphering the molecular players helping to maintain the hybrid E/M phenotype may inform anti-metastasis strategies. Here, we devised a mechanism-based mathematical model to couple the transcription factor OVOL with the core EMT regulatory network miR-200/ZEB that acts as a three-way switch between the E, E/M and M phenotypes. We show that OVOL can modulate cellular plasticity in multiple ways - restricting EMT, driving MET, expanding the existence of the hybrid E/M phenotype and turning both EMT and MET into two-step processes. Our theoretical framework explains the differences between the observed effects of OVOL in breast and prostate cancer, and provides a platform for investigating additional signals during metastasis.asis.
dc.identifier.citationJia, Dongya, Jolly, Mohit Kumar, Boareto, Marcelo, et al.. "OVOL guides the epithelial-hybrid-mesenchymal transition." <i>Oncotarget,</i> 6, no. 17 (2015) Impact Journals, LLC: 15436-15448. http://dx.doi.org/10.18632/oncotarget.3623.
dc.identifier.doihttp://dx.doi.org/10.18632/oncotarget.3623
dc.identifier.urihttps://hdl.handle.net/1911/90519
dc.language.isoeng
dc.publisherImpact Journals, LLC
dc.rightsAll content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subject.keywordEMT
dc.subject.keywordmetastasis
dc.subject.keywordOVOL
dc.subject.keywordpartial EMT
dc.subject.keywordcancer systems biology
dc.titleOVOL guides the epithelial-hybrid-mesenchymal transition
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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