Stability of bacterial toggle switches is enhanced by cell-cycle lengthening by several orders of magnitude

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dc.citation.firstpage22710en_US
dc.citation.journalTitlePhysical Review Een_US
dc.citation.volumeNumber89en_US
dc.contributor.authorJaruszewicz, Joannaen_US
dc.contributor.authorKimmel, Mareken_US
dc.contributor.authorLipniacki, Tomaszen_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgStatisticsen_US
dc.date.accessioned2014-03-12T21:47:26Zen_US
dc.date.available2014-03-12T21:47:26Zen_US
dc.date.issued2014en_US
dc.description.abstractBistable regulatory elements are important for nongenetic inheritance, increase of cell-to-cell heterogeneity allowing adaptation, and robust responses at the population level. Here, we study computationally the bistable genetic toggle switch-a small regulatory network consisting of a pair of mutual repressors-in growing and dividing bacteria. We show that as cells with an inhibited growth exhibit high stability of toggle states, cell growth and divisions lead to a dramatic increase of toggling rates. The toggling rates were found to increase with rate of cell growth, and can be up to six orders of magnitude larger for fast growing cells than for cells with the inhibited growth. The effect is caused mainly by the increase of protein and mRNA burst sizes associated with the faster growth. The observation that fast growth dramatically destabilizes toggle states implies that rapidly growing cells may vigorously explore the epigenetic landscape enabling nongenetic evolution, while cells with inhibited growth adhere to the local optima. This can be a clever population strategy that allows the slow growing (but stress resistant) cells to survive long periods of unfavorable conditions. Simultaneously, at favorable conditions, this stress resistant (but slowly growing?or not growing) subpopulation may be replenished due to a high switching rate from the fast growing population.en_US
dc.identifier.citationJaruszewicz, Joanna, Kimmel, Marek and Lipniacki, Tomasz. "Stability of bacterial toggle switches is enhanced by cell-cycle lengthening by several orders of magnitude." <i>Physical Review E,</i> 89, (2014) American Physical Society: 22710. http://dx.doi.org/10.1103/PhysRevE.89.022710.en_US
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevE.89.022710en_US
dc.identifier.urihttps://hdl.handle.net/1911/75575en_US
dc.language.isoengen_US
dc.publisherAmerican Physical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleStability of bacterial toggle switches is enhanced by cell-cycle lengthening by several orders of magnitudeen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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