Beta activity in human anterior cingulate cortex mediates reward biases

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dc.citation.articleNumber5528en_US
dc.citation.journalTitleNature Communicationsen_US
dc.citation.volumeNumber15en_US
dc.contributor.authorXiao, Jiayangen_US
dc.contributor.authorAdkinson, Joshua A.en_US
dc.contributor.authorMyers, Johnen_US
dc.contributor.authorAllawala, Anusha B.en_US
dc.contributor.authorMathura, Raissa K.en_US
dc.contributor.authorPirtle, Victoriaen_US
dc.contributor.authorNajera, Ricardoen_US
dc.contributor.authorProvenza, Nicole R.en_US
dc.contributor.authorBartoli, Eleonoraen_US
dc.contributor.authorWatrous, Andrew J.en_US
dc.contributor.authorOswalt, Deniseen_US
dc.contributor.authorGadot, Ronen_US
dc.contributor.authorAnand, Adrishen_US
dc.contributor.authorShofty, Benen_US
dc.contributor.authorMathew, Sanjay J.en_US
dc.contributor.authorGoodman, Wayne K.en_US
dc.contributor.authorPouratian, Naderen_US
dc.contributor.authorPitkow, Xaqen_US
dc.contributor.authorBijanki, Kelly R.en_US
dc.contributor.authorHayden, Benjaminen_US
dc.contributor.authorSheth, Sameer A.en_US
dc.date.accessioned2024-08-02T13:32:11Zen_US
dc.date.available2024-08-02T13:32:11Zen_US
dc.date.issued2024en_US
dc.description.abstractThe rewards that we get from our choices and actions can have a major influence on our future behavior. Understanding how reward biasing of behavior is implemented in the brain is important for many reasons, including the fact that diminution in reward biasing is a hallmark of clinical depression. We hypothesized that reward biasing is mediated by the anterior cingulate cortex (ACC), a cortical hub region associated with the integration of reward and executive control and with the etiology of depression. To test this hypothesis, we recorded neural activity during a biased judgment task in patients undergoing intracranial monitoring for either epilepsy or major depressive disorder. We found that beta (12–30 Hz) oscillations in the ACC predicted both associated reward and the size of the choice bias, and also tracked reward receipt, thereby predicting bias on future trials. We found reduced magnitude of bias in depressed patients, in whom the beta-specific effects were correspondingly reduced. Our findings suggest that ACC beta oscillations may orchestrate the learning of reward information to guide adaptive choice, and, more broadly, suggest a potential biomarker for anhedonia and point to future development of interventions to enhance reward impact for therapeutic benefit.en_US
dc.identifier.citationXiao, J., Adkinson, J. A., Myers, J., Allawala, A. B., Mathura, R. K., Pirtle, V., Najera, R., Provenza, N. R., Bartoli, E., Watrous, A. J., Oswalt, D., Gadot, R., Anand, A., Shofty, B., Mathew, S. J., Goodman, W. K., Pouratian, N., Pitkow, X., Bijanki, K. R., … Sheth, S. A. (2024). Beta activity in human anterior cingulate cortex mediates reward biases. Nature Communications, 15(1), 5528. https://doi.org/10.1038/s41467-024-49600-7en_US
dc.identifier.digitals41467-024-49600-7en_US
dc.identifier.doihttps://doi.org/10.1038/s41467-024-49600-7en_US
dc.identifier.urihttps://hdl.handle.net/1911/117586en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleBeta activity in human anterior cingulate cortex mediates reward biasesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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