A Topological Model of the Hippocampal Cell Assembly Network

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dc.citation.articleNumber50
dc.citation.journalTitleFrontiers in Computational Neuroscience
dc.citation.volumeNumber10
dc.contributor.authorBabichev, Andrey
dc.contributor.authorJi, Daoyun
dc.contributor.authorMémoli, Facundo
dc.contributor.authorDabaghian, Yuri A.
dc.date.accessioned2016-07-07T21:09:20Z
dc.date.available2016-07-07T21:09:20Z
dc.date.issued2016
dc.description.abstractIt is widely accepted that the hippocampal place cells' spiking activity produces a cognitive map of space. However, many details of this representation's physiological mechanism remain unknown. For example, it is believed that the place cells exhibiting frequent coactivity form functionally interconnected groups—place cell assemblies—that drive readout neurons in the downstream networks. However, the sheer number of coactive combinations is extremely large, which implies that only a small fraction of them actually gives rise to cell assemblies. The physiological processes responsible for selecting the winning combinations are highly complex and are usually modeled via detailed synaptic and structural plasticity mechanisms. Here we propose an alternative approach that allows modeling the cell assembly network directly, based on a small number of phenomenological selection rules. We then demonstrate that the selected population of place cell assemblies correctly encodes the topology of the environment in biologically plausible time, and may serve as a schematic model of the hippocampal network.
dc.identifier.citationBabichev, Andrey, Ji, Daoyun, Mémoli, Facundo, et al.. "A Topological Model of the Hippocampal Cell Assembly Network." <i>Frontiers in Computational Neuroscience,</i> 10, (2016) Frontiers Media S.A.: http://dx.doi.org/10.3389/fncom.2016.00050.
dc.identifier.doihttp://dx.doi.org/10.3389/fncom.2016.00050
dc.identifier.urihttps://hdl.handle.net/1911/90843
dc.language.isoeng
dc.publisherFrontiers Media S.A.
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.keywordplace cells
dc.subject.keywordhippocampus
dc.subject.keywordcell assemblies
dc.subject.keywordcognitive map
dc.subject.keywordtopology
dc.titleA Topological Model of the Hippocampal Cell Assembly Network
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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