Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields

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dc.citation.firstpage1862
dc.citation.issueNumber7
dc.citation.journalTitleBiomaterials
dc.citation.lastpage1869
dc.citation.volumeNumber34
dc.contributor.authorRaoof, Mustafa
dc.contributor.authorCisneros, Brandon T.
dc.contributor.authorGuven, Adem
dc.contributor.authorCorr, Stuart J.
dc.contributor.authorWilson, Lon J.
dc.contributor.authorCurley, Steven A.
dc.contributor.orgRichard E. Smalley Institute for Nanoscale Science & Technology
dc.date.accessioned2015-07-10T15:47:01Z
dc.date.available2015-07-10T15:47:01Z
dc.date.issued2013
dc.description.abstractThe efficacy of nanoparticle-mediated drug delivery is limited by its peri-vascular sequestration, thus necessitating a strategy to trigger drug release from such intra-tumoral nanocarrier-drug depots. In our efforts to explore remotely-activated nanocarriers, we have developed carbon nanocapsules comprised of an ultra-short carbon nanotube shell (US-tubes) loaded with cisplatin (CDDP@US-tubes) and covered with a Pluronic surfactant wrapping to minimize passive release. We demonstrate here that non-invasive radiofrequency (RF) field activation of the CDDP@US-tubes produces heat that causes Pluronic disruption which triggers cisplatin release in an RF-dependent manner. Furthermore, release-dependent cytotoxicity is demonstrated in human hepatocellular carcinoma cell lines.
dc.identifier.citationRaoof, Mustafa, Cisneros, Brandon T., Guven, Adem, et al.. "Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields." <i>Biomaterials,</i> 34, no. 7 (2013) Elsevier: 1862-1869. http://dx.doi.org/10.1016/j.biomaterials.2012.11.033.
dc.identifier.doihttp://dx.doi.org/10.1016/j.biomaterials.2012.11.033
dc.identifier.urihttps://hdl.handle.net/1911/80882
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.subject.keywordradiofrequency field
dc.subject.keywordcarbon nanotubes
dc.subject.keywordUS-tubes
dc.subject.keywordtriggered release
dc.subject.keywordliver cancer
dc.subject.keywordcisplatin
dc.titleRemotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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