Fabrication and characterization of multiscale electrospun scaffolds for cartilage regeneration

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dc.citation.firstpage14103en_US
dc.citation.journalTitleBiomedical Materialsen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorLevorson, Erica J.en_US
dc.contributor.authorSreerekha, Perumcherry Ramanen_US
dc.contributor.authorChennazhi, Krishna Prasaden_US
dc.contributor.authorKasper, F. Kurtisen_US
dc.contributor.authorNair, Shantikumar V.en_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgChemical and Biomolecular Engineeringen_US
dc.date.accessioned2013-03-19T15:32:36Zen_US
dc.date.available2014-03-20T05:10:04Zen_US
dc.date.issued2013en_US
dc.description.abstractRecently, scaffolds for tissue regeneration purposes have been observed to utilize nanoscale features in an effort to reap the cellular benefits of scaffold features resembling extracellular matrix (ECM) components. However, one complication surrounding electrospun nanofibers is limited cellular infiltration. One method to ameliorate this negative effect is by incorporating nanofibers into microfibrous scaffolds. This study shows that it is feasible to fabricate electrospun scaffolds containing two differently scaled fibers interspersed evenly throughout the entire construct as well as scaffolds containing fibers composed of two discrete materials, specifically fibrin and poly(? caprolactone). In order to accomplish this, multiscale fibrous scaffolds of different compositions were generated using a dual extrusion electrospinning setup with a rotating mandrel. These scaffolds were then characterized for fiber diameter, porosity and pore size and seeded with human mesenchymal stem cells to assess the influence of scaffold architecture and composition on cellular responses as determined by cellularity, histology and glycosaminoglycan (GAG) content. Analysis revealed that nanofibers within aen_US
dc.embargo.terms1 yearen_US
dc.identifier.citationLevorson, Erica J., Sreerekha, Perumcherry Raman, Chennazhi, Krishna Prasad, et al.. "Fabrication and characterization of multiscale electrospun scaffolds for cartilage regeneration." <i>Biomedical Materials,</i> 8, (2013) IOP Publishing: 14103. http://dx.doi.org/10.1088/1748-6041/8/1/014103.en_US
dc.identifier.doihttp://dx.doi.org/10.1088/1748-6041/8/1/014103en_US
dc.identifier.urihttps://hdl.handle.net/1911/70714en_US
dc.language.isoengen_US
dc.publisherIOP Publishingen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleFabrication and characterization of multiscale electrospun scaffolds for cartilage regenerationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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