Analysis of sex-based differences in clinical and molecular responses to ischemia reperfusion after lung transplantation

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dc.citation.articleNumber318en_US
dc.citation.journalTitleRespiratory Researchen_US
dc.citation.volumeNumber22en_US
dc.contributor.authorChacon-Alberty, Lourdesen_US
dc.contributor.authorYe, Shengbinen_US
dc.contributor.authorDaoud, Daouden_US
dc.contributor.authorFrankel, William C.en_US
dc.contributor.authorVirk, Hassanen_US
dc.contributor.authorMase, Jonathanen_US
dc.contributor.authorHochman-Mendez, Camilaen_US
dc.contributor.authorLi, Mengen_US
dc.contributor.authorSampaio, Luiz C.en_US
dc.contributor.authorTaylor, Doris A.en_US
dc.contributor.authorLoor, Gabrielen_US
dc.date.accessioned2022-01-07T16:17:19Zen_US
dc.date.available2022-01-07T16:17:19Zen_US
dc.date.issued2021en_US
dc.description.abstractBackground: Sex and hormones influence immune responses to ischemia reperfusion (IR) and could, therefore, cause sex-related differences in lung transplantation (LTx) outcomes. We compared men’s and women’s clinical and molecular responses to post-LTx IR. Methods: In 203 LTx patients, we used the 2016 International Society for Heart and Lung Transplantation guidelines to score primary graft dysfunction (PGD). In a subgroup of 40 patients with blood samples collected before LTx (T0) and 6, 24, 48 (T48), and 72 h (T72) after lung reperfusion, molecular response to IR was examined through serial analysis of circulating cytokine expression. Results: After adjustment, women had less grade 3 PGD than men at T48, but not at T72. PGD grade decreased from T0 to T72 more often in women than men. The evolution of PGD (the difference in mean PGD between T72 and T0) was greater in men. However, the evolution of IL-2, IL-7, IL-17a, and basic fibroblast growth factor levels was more often sustained throughout the 72 h in women. In the full cohort, we noted no sex differences in secondary clinical outcomes, but women had significantly lower peak lactate levels than men across the 72 h. Conclusions: Men and women differ in the evolution of PGD and cytokine secretion after LTx: Women have a more sustained proinflammatory response than men despite a greater reduction in PGD over time. This interaction between cytokine and PGD responses warrants investigation. Additionally, there may be important sex-related differences that could be used to tailor treatment during or after transplantation.en_US
dc.identifier.citationChacon-Alberty, Lourdes, Ye, Shengbin, Daoud, Daoud, et al.. "Analysis of sex-based differences in clinical and molecular responses to ischemia reperfusion after lung transplantation." <i>Respiratory Research,</i> 22, (2021) Springer Nature: https://doi.org/10.1186/s12931-021-01900-y.en_US
dc.identifier.digitalChacon-Alberty2021en_US
dc.identifier.doihttps://doi.org/10.1186/s12931-021-01900-yen_US
dc.identifier.urihttps://hdl.handle.net/1911/111909en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/.en_US
dc.titleAnalysis of sex-based differences in clinical and molecular responses to ischemia reperfusion after lung transplantationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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