Physical and electrical characterization of TexasPEG: An electrically conductive neuronal scaffold

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dc.citation.articleNumber84
dc.citation.journalTitleSurgical Neurology International
dc.citation.volumeNumber8
dc.contributor.authorSikkema, William K.A.
dc.contributor.authorMetzger, Andrew B.
dc.contributor.authorWang, Tuo
dc.contributor.authorTour, James M.
dc.date.accessioned2017-07-25T18:04:14Z
dc.date.available2017-07-25T18:04:14Z
dc.date.issued2017
dc.description.abstractBackground: Graphene and its derivatives have been shown to be biocompatible and electrically active materials upon which neurons readily grow. The fusogen poly(ethylene glycol) (PEG) has been shown to improve outcomes after cervical and dorsal spinal cord transection. The long and narrow PEGylated graphene nanoribbon stacks (PEG-GNRs) with their 5 μm × 200 nm × 10 nm dimensions can provide a scaffold upon which neurons can grow and fuse. We disclose here the extensive characterization data for the PEG-GNRs. Methods: PEG-GNRs were chemically synthesized and chemically and electrically characterized. Results: The average aspect ratio of the PEG-GNRs was determined to be ~85, which corresponds to a critical percolation value (the point where insulating material becomes conductive by addition of conductive particles) of 1%. However, there was not a sharp increase in AC conductivity at frequencies relevant to action potentials. Conclusion: A robust characterization of PEG-GNRs is discussed, though the precise origin of efficacy in improving outcomes following spinal cord transection is not known.
dc.identifier.citationSikkema, William K.A., Metzger, Andrew B., Wang, Tuo, et al.. "Physical and electrical characterization of TexasPEG: An electrically conductive neuronal scaffold." <i>Surgical Neurology International,</i> 8, (2017) Wolters Kluwer - Medknow: https://doi.org/10.4103/sni.sni_361_16.
dc.identifier.digitalTexasPEG
dc.identifier.doihttps://doi.org/10.4103/sni.sni_361_16
dc.identifier.urihttps://hdl.handle.net/1911/95226
dc.language.isoeng
dc.publisherWolters Kluwer - Medknow
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.subject.keywordFusogen
dc.subject.keywordgraphene
dc.subject.keywordnanoribbons
dc.subject.keywordPEG
dc.titlePhysical and electrical characterization of TexasPEG: An electrically conductive neuronal scaffold
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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